Table 2

Outcomes included in the SCORE-IT core outcome set

OutcomeDomain
Glycemic control: how well someone’s blood glucose is controlled.Physiological/clinical
Global quality of life: someone’s overall quality of life, including physical, mental and social well-being.Life impact
Activities of daily living: being able to complete usual everyday tasks and activities, including those related to personal care, household tasks or community-based tasks.Life impact
Body weight: how much someone weighs.Physiological/clinical
Kidney function: how well someone’s kidneys are working.Physiological/clinical
Hyperglycemia: how often someone has high blood glucose.Physiological/clinical
Hypoglycemia: how often someone has low blood glucose levels.Physiological/clinical
Visual deterioration or blindness: if someone’s eyesight gets worse or if they have loss of vision including blindness.Physiological/clinical
Neuropathy: damage to the nerves caused by high glucose. This can lead to tingling and pain or numbness in the feet or legs. It can also affect bowel control, stomach emptying and sexual function.Physiological/clinical
Having gangrene or having an amputation of the leg, foot or toe.Physiological/clinical
Non-fatal myocardial infarction: having a heart attack that is not fatal.Physiological/clinical
Heart failure.Physiological/clinical
Cerebrovascular disease, including stroke, subarachnoid hemorrhage, transient ischemic attack and vascular dementia.Physiological/clinical
How often someone is admitted to hospital because of their diabetes.Resource use
Hyperglycemic emergencies (to include diabetic ketoacidosis and hyperosmolar hyperglycemic state).Physiological/clinical
Side effects of treatment: any unwanted effects of the treatment.Adverse events
Overall survival: how long someone lives.Death
Death from a diabetes-related cause, such as heart disease.Death
  • SCORE-IT, Selecting Core Outcomes for Randomised Effectiveness trials In Type 2 diabetes.