Table 2

Sensitivity analyses

Outcomes	Events	Person-year	Incidence density†	Crude		Model A‡		Model B§
Outcomes	Events	Person-year	Incidence density†	HR	95% CI	HR	95% CI	HR	95% CI
Incident renal stones
FRAIL item count
0	10 740	1,482,324.0	7.3	1	–	1	–	1	–
1	4843	591 942.6	8.2	1.11	1.08 to 1.15***	1.05	0.998 to 1.11	1.05	0.99 to 1.10
2	1075	120 967.6	8.9	1.19	1.12 to 1.27***	1.27	1.15 to 1.41***	1.27	1.15 to 1.41***
≥3	89	8566.9	10.4	1.36	1.10 to 1.67**	1.47	1.10 to 1.96*	1.49	1.11 to 1.99**
Every 1 item increase				1.10	1.08 to 1.13***	1.10	1.05 to 1.14***	1.09	1.05 to 1.14***
Incident lower urinary tract stones
FRAIL item count
0	938	1 512 864.8	0.6	1	–	1	–	1	–
1	613	604 530.9	1.0	1.63	1.47 to 1.80***	0.95	0.81 to 1.11	0.94	0.80 to 1.10
2	166	123 660.5	1.3	2.14	1.82 to 2.53***	0.97	0.74 to 1.27	0.97	0.74 to 1.26
≥3	25	8726.1	2.9	4.52	3.04 to 6.73***	1.08	0.61 to 1.94	1.09	0.60 to 1.95
Every 1 item increase				1.54	1.44 to 1.64***	0.98	0.87 to 1.11	0.98	0.87 to 1.11
Recurrent urolithiasis
FRAIL item count
0	6090	1 467 976.6	4.2	1	–	1	–	1	–
1	2603	584 707.2	4.5	1.06	1.01 to 1.11*	1.12	1.04 to 1.20**	1.11	1.04 to 1.20**
2	509	119 237.0	4.3	1.00	0.91 to 1.09	1.35	1.17 to 1.55***	1.35	1.17 to 1.55***
≥3	41	8365.2	4.9	1.11	0.82 to 1.51	2.06	1.31 to 3.24**	2.08	1.33 to 3.27**
Every 1 item increase				1.03	1.00 to 1.06	1.15	1.08 to 1.22***	1.15	1.08 to 1.22***

*P<0.05; **P<0.01; P<0.001.
†per 1000 patient-year.
‡Incorporating age category/gender, lifestyle factors, the year of DM diagnosis, comorbidities, aDCSI, change of frailty status during follow-up, and all medications except oral antidiabetic agents.
§Model A adding oral antidiabetic agents.
aDCSI, adapted diabetes complications severity index; CI, confidence interval; DM, diabetes mellitus; HR, hazard ratio.