Relative risks (95% CI)* of type 2 diabetes associated with the genetic risk scores (GRS) for type 2 diabetes among women with a history of gestational diabetes in the NHSII (n=1884) and the (n=550)
| GRS quartiles | P trend | Per five allele increment | |||||
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||||
| NHSII | Range | 33.7–64.0 | 64.0–68.0 | 68.0–72.0 | 72.0–86.0 | ||
| Case/total (%) | 98/436 (22.5) | 97/472 (20.6) | 128/497 (25.8) | 123/479 (25.7) | |||
| RR (95% CI) | 1.00 | 0.93 (0.72 to 1.19) | 1.16 (0.92 to 1.46) | 1.17 (0.93 to 1.48) | 0.07 | 1.07 (1.00 to 1.15) | |
| DNBC | Range | 51.6–63.1 | 63.1–67.6 | 67.9–71.0 | 71.2–82.0 | ||
| Case/total (%) | 32/138 (23.2) | 35/137 (25.5) | 50/139 (36.0) | 38/136 (27.9) | |||
| RR (95% CI) | 1.00 | 1.13 (0.75 to 1.71) | 1.54 (1.06 to 2.24) | 1.23 (0.82 to 1.84) | 0.17 | 1.09 (0.96 to 1.23) | |
| Pooled† | RR (95% CI) | 1.00 | 0.97 (0.79 to 1.21) | 1.25 (1.03 to 1.52) | 1.19 (0.97 to 1.45) | 0.02 | 1.07 (1.01 to 1.14) |
*Estimated in log-binomial models adjusting for women’s year of birth.
†Meta-analyzed results from the two cohorts using fixed effects models weighted by inverse variance of the estimates; there is no significant heterogeneity across results from the two cohorts (p value for Q>0.05).
DNBC, Danish National Birth Cohort; NHSII, Nurses’ Health Study II; RR, relative risk.