Table 4

The cumulative effect of DR-related SNPs on diabetic patients with ERFD* outcomes in the multivariate logistic regression model

N (%)
N (%)
OR95% CIP value
Follow-up duration (years)0.590.51 to 0.67<0.001
Urine creatinine (mg/dL)0.9980.996 to 1.0000.074
Genetic risk score
 Q1 (<37.58)111 (32.6)117 (34.0)Ref.Ref.Ref.
 Q2 (37.58 to 40.23)105 (30.8)124 (36.0)1.160.76 to 1.770.502
 Q3 (>40.23)125 (36.7)103 (29.9)0.890.58 to 1.370.597
  • Values are presented as N (%) or mean±SD.

  • The genetic risk score was calculated based on 33 SNPs listed in online supplementary table S2.

  • *Early renal function decline was defined as >3.3 mL/min/1.73 m2 decline in the eGFR per year.

  • †Represents a p value <0.001.

  • DR, diabetic retinopathy; eGFR, estimated glomerular filtration rate; ERFD, early renal functional decline; Q, quantile; Ref, reference; SNP, single nucleotide polymorphisms.