The cumulative effect of DR-related SNPs on diabetic patients with ERFD* outcomes in the multivariate logistic regression model
| Non-ERFD N (%) | ERFD N (%) | OR | 95% CI | P value | |
| Follow-up duration (years) | 0.59 | 0.51 to 0.67 | <0.001† | ||
| Urine creatinine (mg/dL) | 0.998 | 0.996 to 1.000 | 0.074 | ||
| Genetic risk score | |||||
| Q1 (<37.58) | 111 (32.6) | 117 (34.0) | Ref. | Ref. | Ref. |
| Q2 (37.58 to 40.23) | 105 (30.8) | 124 (36.0) | 1.16 | 0.76 to 1.77 | 0.502 |
| Q3 (>40.23) | 125 (36.7) | 103 (29.9) | 0.89 | 0.58 to 1.37 | 0.597 |
Values are presented as N (%) or mean±SD.
The genetic risk score was calculated based on 33 SNPs listed in online supplementary table S2.
*Early renal function decline was defined as >3.3 mL/min/1.73 m2 decline in the eGFR per year.
†Represents a p value <0.001.
DR, diabetic retinopathy; eGFR, estimated glomerular filtration rate; ERFD, early renal functional decline; Q, quantile; Ref, reference; SNP, single nucleotide polymorphisms.