Table 2

The cumulative effect of DR-related SNPs on patients with diabetes with different eGFR status in the multivariate logistic regression model

eGFR* >90
N (%)
eGFR <60
N (%)
OR95% CIP value
Age (years)1.181.15 to 1.21<0.001†
BMI (kg/m2)1.101.04 to 1.160.001‡
HDL (mg/dL)0.980.97 to 1.000.050
LDL (mg/dL)1.000.99 to 1.000.135
ACR (mg/g)1.0011.001 to 1.002<0.001†
Genetic risk score
 Q1 (<37.74)251 (34.5)147 (31.3)Ref.Ref.Ref.
 Q2 (37.74 to 40.42)226 (31.1)174 (37.1)1.651.01 to 2.720.048‡
 Q3 (>40.42)250 (34.4)148 (31.6)1.200.72 to 2.010.483
  • The genetic risk score was calculated based on 33 SNPs listed in online supplementary table S2.

  • *The Modified Diet in Renal Disease equation was used to estimate eGFR.

  • †Represents a p value <0.001.

  • ‡Represents a p value <0.05.

  • ACR, albumin-to-creatinine ratio; BMI, body mass index; DR, diabetic retinopathy; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Q, quantile; Ref, reference; SNP, single nucleotide polymorphisms.