The cumulative effect of DR-related SNPs on patients with diabetes with different eGFR status in the multivariate logistic regression model
| eGFR* >90 N (%) | eGFR <60 N (%) | OR | 95% CI | P value | |
| Age (years) | 1.18 | 1.15 to 1.21 | <0.001† | ||
| BMI (kg/m2) | 1.10 | 1.04 to 1.16 | 0.001‡ | ||
| HDL (mg/dL) | 0.98 | 0.97 to 1.00 | 0.050 | ||
| LDL (mg/dL) | 1.00 | 0.99 to 1.00 | 0.135 | ||
| ACR (mg/g) | 1.001 | 1.001 to 1.002 | <0.001† | ||
| Genetic risk score | |||||
| Q1 (<37.74) | 251 (34.5) | 147 (31.3) | Ref. | Ref. | Ref. |
| Q2 (37.74 to 40.42) | 226 (31.1) | 174 (37.1) | 1.65 | 1.01 to 2.72 | 0.048‡ |
| Q3 (>40.42) | 250 (34.4) | 148 (31.6) | 1.20 | 0.72 to 2.01 | 0.483 |
The genetic risk score was calculated based on 33 SNPs listed in online supplementary table S2.
*The Modified Diet in Renal Disease equation was used to estimate eGFR.
†Represents a p value <0.001.
‡Represents a p value <0.05.
ACR, albumin-to-creatinine ratio; BMI, body mass index; DR, diabetic retinopathy; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Q, quantile; Ref, reference; SNP, single nucleotide polymorphisms.