Δ 2 hours | Δ 6 hours | Group | Time | Group×time | |||
Proinflammatory genes | TNFα | FDRT | 1.36±0.10 | 1.80±0.16 | 0.001 | 0.001 | 0.007 |
Non-FDRT | 1.06±0.08 | 1.17±0.07 | |||||
IL-6 | FDRT | 1.33±0.56 | 6.73±2.38 | 0.089 | 0.002 | 0.153 | |
Non-FDRT | 0.56±0.16 | 2.68±0.89 | |||||
MCP-1 | FDRT | 0.99±0.20 | 5.16±2.06 | 0.116 | 0.005 | 0.159 | |
Non-FDRT | 0.61±0.09 | 2.00±0.37 | |||||
TLR4 | FDRT | 1.03±0.08 | 1.34±0.12 | 0.397 | 0.001 | 0.417 | |
Non-FDRT | 1.02±0.07 | 1.19±0.06 | |||||
IL-1β | FDRT | 0.91±0.08 | 1.30±0.20 | 0.916 | 0.008 | 0.817 | |
Non-FDRT | 0.96±0.07 | 1.22±0.08 | |||||
NF-κB/p105 | FDRT | 1.00±0.07 | 1.11±0.06 | 0.209 | 0.741 | 0.106 | |
Non-FDRT | 0.99±0.05 | 0.93±0.07 | |||||
Rel-A | FDRT | 1.00±0.05 | 1.39±0.15 | 0.112 | 0.001 | 0.220 | |
Non-FDRT | 0.90±0.06 | 1.13±0.07 | |||||
Anti-inflammatory genes | IκB-β | FDRT | 1.00±0.09 | 1.64±0.29 | 0.137 | 0.001 | 0.355 |
Non-FDRT | 0.89±0.04 | 1.26±0.11 | |||||
IκB-α | FDRT | 0.89±0.03 | 1.03±0.05 | 0.781 | 0.005 | 0.254 | |
Non-FDRT | 0.92±0.05 | 0.97±0.04 | |||||
IL-10 | FDRT | 1.54±0.33 | 8.94±3.43 | 0.057 | 0.004 | 0.077 | |
Non-FDRT | 0.72±0.19 | 2.57±0.67 | |||||
TGFβ | FDRT | 1.04±0.04 | 1.09±0.07 | 0.114 | 0.004 | 0.114 | |
Non-FDRT | 1.24±0.12 | 1.31±0.13 | |||||
Cytokine | IL-6 (plasma) | FDRT | 0.64±0.16 | 1.02±0.13 | 0.349 | 0.001 | 0.606 |
Non-FDRT | 0.43±0.10 | 0.98±0.18 |
Data are mean±SEM. P<0.05 using a linear mixed model. Numbers in bold represent significant values.
FDRT, first-degree relative with type 2 diabetes mellitus; IL-6, interleukin-6; MCP-1, monocyte chemoattractant protein-1; MNC, mononuclear cell; NF-κB, nuclear factor kappa B; TGFβ, transforming growth factor-β; TLR4, Toll-like receptor 4; TNFα, tumor necrosis factor alpha.