Table 3

Receiver operating characteristics (ROC) curve for potential predictors of diabetes

ParameterAUCROC (95% CI)Cut-offP value of AUCROC compared with HbA1cSensitivitySpecificityPPVNPV
HbA1c, mmol/mol (%)0.90 (0.83 to 0.98)48 (6.5)*
UMIwake-up, mg/gCr0.64 (0.49 to 0.78)18<0.0010.730.490.270.87
UMIpremeal, mg/gCr0.62 (0.48 to 0.76)14<0.00010.640.400.230.80
UMI2h-postprandial, mg/gCr0.83 (0.73 to 0.93)320.130.760.810.530.92
ΔUMI, mg/gCr0.82 (0.71 to 0.93)
  • ΔUMI was defined as 2-hour postprandial UMI minus premeal UMI.

  • *American Diabetes Association criteria for diabetes as HbA1c ≥48 mmol/mol (6.5%) was used as reference standard.

  • AUCROC, area under the ROC curve; NPV, negative predictive value; PPV, positive predictive value; UMI, urinary myoinositol; UMI2h-postprandial, UMI at 2-hour postprandial; UMIpremeal, UMI at premeal (fasting second urine); UMIwake-up, UMI at wake-up time (fasting first urine).