SNP-risk allele | Gene | Effect size on uric acid levels | Observed association with diabetes risk | Expected association with diabetes risk | Observed association with diabetes risk adjusted for uric acid | ||||
β (95% CI)* | P value | OR (95% CI)† | P value | OR (95% CI) | P value‡ | OR (95% CI) | P value | ||
rs1471633-A | PDZK1 | 0.05(0.01 to 0.08) | 1.73×10−2 | 0.95 (0.86 to 1.05) | 0.35 | 1.005 (1.005 to 1.005) | 0.31 | 0.95 (0.86 to 1.05) | 0.34 |
rs11264341-C | TRIM46 | 0.07 (0.04 to 0.11) | 1.78×10−5 | 1.01 (0.92 to 1.10) | 0.82 | 1.008 (1.008 to 1.008) | 0.96 | 1.01 (0.92 to 1.10) | 0.86 |
rs1165151-G | SLC17A1 | 0.09 (0.05 to 0.13) | 1.38×10−6 | 1.03 (0.94 to 1.13) | 0.53 | 1.009 (1.009 to 1.009) | 0.67 | 1.03 (0.93 to 1.13) | 0.58 |
rs6770152-G | SERBP1P3 | 0.04 (0.01 to 0.06) | 1.33×10−2 | 1.02 (0.95 to 1.10) | 0.52 | 1.004 (1.004 to 1.004) | 0.59 | 1.02 (0.95 to 1.10) | 0.54 |
rs478607-G | NRXN2 | 0.06 (0.02 to 0.10) | 1.11×10−3 | 0.99 (0.91 to 1.09) | 0.89 | 1.006 (1.006 to 1.006) | 0.79 | 0.99 (0.91 to 1.09) | 0.86 |
rs11722228-T | SLC2A9 | 0.14 (0.11 to 0.17) | 6.53×10−20 | 0.97 (0.89 to 1.06) | 0.52 | 1.015 (1.015 to 1.015) | 0.31 | 0.97 (0.89 to 1.05) | 0.45 |
rs3775948-C | SLC2A9 | 0.17 (0.14 to 0.19) | 8.11×10−30 | 1.00 (0.93 to 1.08) | 0.92 | 1.017 (1.017 to 1.017) | 0.65 | 1.00 (0.92 to 1.07) | 0.89 |
rs2231142-T | ABCG2 | 0.16 (0.13 to 0.19) | 1.14×10−25 | 1.04 (0.93 to 1.13) | 0.32 | 1.017 (1.017 to 1.017) | 0.56 | 1.04 (0.96 to 1.12) | 0.39 |
rs3114018-C | ABCG2 | 0.12 (0.09 to 0.15) | 3.07×10−15 | 1.02 (0.94 to 1.10) | 0.64 | 1.012 (1.012 to 1.012) | 0.88 | 1.01 (0.94 to 1.10) | 0.72 |
rs2544390-T | LRP2 | 0.05 (0.02 to 0.08) | 1.00×10−3 | 1.04 (0.96 to 1.12) | 0.3 | 1.005 (1.005 to 1.005) | 0.37 | 1.04 (0.96 to 1.12) | 0.33 |
rs17786744-G | STC1 | 0.03 (0.01 to 0.06) | 2.77×10−2 | 1.00 (0.92 to 1.08) | 0.98 | 1.003 (1.003 to 0.003) | 0.91 | 1.00 (0.92 to 1.08) | 0.95 |
rs2941484-T | HNF4G | 0.04 (0.01 to 0.07) | 7.88×10−3 | 0.97 (0.90 to 1.05) | 0.54 | 1.004 (1.004 to 1.004) | 0.48 | 0.97 (0.90 to 1.05) | 0.52 |
rs505802-C | SLC22A12 | 0.05 (0.02 to 0.09) | 1.69×10−3 | 0.98 (0.90 to 1.08) | 0.75 | 1.006 (1.005 to 1.005) | 0.66 | 0.98 (0.90 to 1.07) | 0.73 |
rs6598541-A | IGF1R | 0.03 (0.01 to 0.06) | 2.11×10−2 | 1.05 (0.97 to 1.13) | 0.22 | 1.003 (1.003 to 0.003) | 0.26 | 1.05 (0.97 to 1.13) | 0.23 |
rs2079742-T | BCAS3 | 0.03 (0.01 to 0.06) | 2.44×10−2 | 0.95 (0.88 to 1.02) | 0.17 | 1.003 (1.003 to 0.003) | 0.14 | 0.95 (0.88 to 1.02) | 0.15 |
GRS | 0.17 (0.15 to 0.19) | 2.81×10−67 | 1.01 (0.95 to 1.06) | 0.75 | 1.018 (1.018 to 1.018) | 0.72 | 1.01 (0.96 to 1.06) | 0.75 |
*Estimates from linear regression (additive genetic model) on serum uric acid levels ranks per one risk allele increase, adjusted for age, sex, body mass index, smoking status, drinking status, physical activity, and estimated glomerular filtration rate. Computed normal scores of uric acid levels from the ranks were used to calculate β estimates.
†Estimates from logistic regression model (additive genetic model) on diabetes risk per one risk allele increase, adjusted for age, sex, body mass index, smoking status, drinking status, physical activity, education levels, estimated glomerular filtration rate, hypertension, hyperlipidemia and family history of diabetes.
‡P value for difference between expected and observed association with diabetes risk.
GRS, genetic risk score.