Performance of serum GP73 and CK18-M30 levels in diagnosing NASH in patients with persistent nALT
| Tests results | Liver pathology results | Accuracy (%) | Se (%) | Sp (%) | PPV | NPV | P value* | |
| NASH | Non-NASH | |||||||
| GP73 | ||||||||
| Positive predictive | 41 | 35 | 0.552 | 0.773 | 0.327 | 0.539 | 0.586 | 0.707 |
| Negative predictive | 12 | 17 | ||||||
| CK18-M30 | ||||||||
| Positive predictive | 5 | 1 | 0.516 | 0.100 | 0.978 | 0.821 | 0.516 | |
| Negative predictive | 45 | 44 | ||||||
10 missing values in serum CK18-M30.
Diagnostic accuracy was calculated as the sum of true positive and true negative values divided by the total number of observations.
The cut-off value for normal serum ALT was <40 U/L for both sexes. Test results above the cut-off value (53 ng/mL for GP73 and 200 U/L for CK18-M30) were considered predictive of NASH.
*χ2 test for comparing the diagnostic accuracy of serum GP73 and CK18-M30 levels.
ALT, alanine aminotransferase; CK18-M30, cytokeratin-18 M30 fragments; GP73, Golgi protein 73; nALT, normal ALT; NASH, non-alcoholic steatohepatitis; NPV, negative predictive value; PPV, positive predictive value; Se, sensitivity; Sp, specificity.