Table 1

Baseline variables sorted by albuminuria and eGFR (n=2385)

No DKD
(n=1155)
Low eGFR† group (n=281)Albuminuria‡ group (n=514)Low eGFR and albuminuria group (n=435)Overall
(N=2385)
Male714 (62%)171 (61%)333 (65%)280 (64%)1498 (63%)
Age (years)62 (52–70)70 (65–76)***61 (54–69)66 (59–75)***64 (55–71)
BMI (kg/m²)24 (22–27)25 (23–28)*25 (22–28)**25 (23–28)**24 (22–27)
Serum creatinine (mg/dL)0.69 (0.6–0.81)1.02 (0.88–1.14)***0.71 (0.6–0.83)*1.2 (1.02–1.6)***0.79 (0.64–0.96)
eGFR (mL/min/1.73 m2)79 (70–92)52 (46–56)***77 (68–90) *44 (33–52)***70 (56–85)
Total cholesterol (mg/dL)184 (163–207)177 (156–197)**189 (166–211)187 (162–217)185 (162–209)
LDL cholesterol (mg/dL)104 (86–123)100 (79–116)**104 (86–124)97 (81–114)***102 (84–121)
HDL cholesterol (mg/dL)52 (43–64)51 (42–62)51 (43–61)49 (42–62)51 (43–63)
Triglycerides (mg/dL)110 (77–164)115 (88–163)126 (86–182)***121 (92–181)***116 (83–170)
HbA1c§ (%)7.1 (6.6–7.9)6.9 (6.5–7.5)**7.6 (6.8–8.7)***6.9 (6.3–7.7)***7.1 (6.5–8.0)
Uric acid (mg/dL)4.9 (4.1–5.8)5.8 (5.0–6.6)***5.2 (4.3–6.2)***6.2 (5.3–7.1)***5.2 (4.4–6.2)
Systolic blood pressure (mm Hg)126 (118–136)126 (114–138)133 (121–146)***140 (126–152)***130 (119–142)
Diastolic blood pressure (mm Hg)73 (66–80)70 (64–76)**77 (69–84)***73 (65–80)73 (66–81)
History of diabetic retinopathy (yes/no)142 (22%)44 (27%)145 (53%)***216 (66%)***547 (22.9%)
  • The values are expressed in n (%) or median (IQR).

  • *p<0.05, **p<0.01, ***p<0.001.

  • †eGFR <60 mL/min/1.73 m2 and normoalbuminuria (ACR <30 mg/gCr).

  • ‡ACR ≥30 mg/gCr and normal eGFR (≥60 mL/min/1.73 m2).

  • §NGSP, National Glycohemoglobin Standardization Program.

  • ACR, urinary albumin to creatinine ratio; BMI, body mass index; DKD, diabetic kidney disease; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein.