Measured non-imaging and imaging renal functional parameters in healthy subjects as well as in T2DMbaseline and T2DMSGLT2i
| Renal parameters (mean±SD) | Healthy individuals | Patients with type 2 diabetes | P value | |
| T2DMbaseline | T2DMSGLT2i | |||
| Creatinine (mg/dL) | 0.9±0.16 | 0.9±0.21 | 0.95±0.23 | NS |
| GFR (mL/min/1.73 m²) | 122±21*† | 92±22* | 86±24† | 0.001*† |
| MTT (min) | 4.3±1.8* | 5.7±3.0*‡ | 4.4±2.2‡ | 0.012*, 0.004‡ |
| GRP | 5.1±1.1 | 4.7±1.0‡ | 5.2±0.8‡ | 0.02‡ |
*Significant differences between healthy subjects and T2DMbaseline.
†Significant differences between healthy subjects and T2DMSGLT2i.
‡Significant differences between T2DMbaseline and T2DMSGLT2i.
GFR, glomerular filtration rate; GRP, general renal performance; MTT, mean transit time; NS, not significant; SGLT2i, sodium-glucose linked transporter-2 inhibitor; T2DM, type 2 diabetes mellitus.