Table 3

Measured non-imaging and imaging renal functional parameters in healthy subjects as well as in T2DMbaseline and T2DMSGLT2i

Renal parameters
Healthy individualsPatients with type 2 diabetesP value
Creatinine (mg/dL)0.9±0.160.9±0.210.95±0.23NS
GFR (mL/min/1.73 m²)122±21*†92±22*86±24†0.001*†
MTT (min)4.3±1.8*5.7±3.0*‡4.4±2.2‡0.012*, 0.004‡
  • *Significant differences between healthy subjects and T2DMbaseline.

  • †Significant differences between healthy subjects and T2DMSGLT2i.

  • ‡Significant differences between T2DMbaseline and T2DMSGLT2i.

  • GFR, glomerular filtration rate; GRP, general renal performance; MTT, mean transit time; NS, not significant; SGLT2i, sodium-glucose linked transporter-2 inhibitor; T2DM, type 2 diabetes mellitus.