Table 3

Baseline risk factors of eGFR decline on multiple regression analysis and the rapidly lowering group (group 1) by trajectory analysis

VariablesMultiple regression analysisTrajectory analysis
Regression coefficient95% CIOR95% CI
Sex (female)0.036−0.44 to 0.521.090.78 to 1.52
Age (by 10 years)−0.44−0.65, to −0.231.381.19 to 1.60
BMI (by 5 kg/m²)−0.0098−0.27 to 0.250.980.87 to 1.09
HDL cholesterol (by 10 mg/dL)0.11−0.057 to 0.280.950.84 to 1.07
Total cholesterol (by 10 mg/dL)−0.034−0.11 to 0.0461.020.96 to 1.07
Triglycerides (by 10 mg/dL)−0.021−0.052 to 0.0101.020.998 to 1.03
HbA1c* (%)0.031−0.18 to to 1.26
Uric acid (mg/dL)0.050−0.16 to to 1.20
Systolic blood pressure (by 10 mm Hg)−0.17−0.30 to −0.0381.050.95 to 1.15
ACR (by 10 mg/gCr)−0.019−0.027 to −0.0101.0041.001 to 1.008
eGFR (by 10 mL/min/1.73 m2)−0.85−1.03 to −0.681.861.65 to 2.11
  • Calculated by multiple regression analysis as to yearly change of eGFR to identify the baseline risk factors weighting by the square of follow-up period.

  • Calculated by multiple logistic regression analysis in contradistinction to moderate lowering group (group 2).

  • *NGSP, National Glycohemoglobin Standardization Program.

  • ACR, urinary albumin to creatinine ratio; BMI, body mass index; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein.