Baseline risk factors of eGFR decline on multiple regression analysis and the rapidly lowering group (group 1) by trajectory analysis
| Variables | Multiple regression analysis | Trajectory analysis | ||
| Regression coefficient | 95% CI | OR | 95% CI | |
| Sex (female) | 0.036 | −0.44 to 0.52 | 1.09 | 0.78 to 1.52 |
| Age (by 10 years) | −0.44 | −0.65, to −0.23 | 1.38 | 1.19 to 1.60 |
| BMI (by 5 kg/m²) | −0.0098 | −0.27 to 0.25 | 0.98 | 0.87 to 1.09 |
| HDL cholesterol (by 10 mg/dL) | 0.11 | −0.057 to 0.28 | 0.95 | 0.84 to 1.07 |
| Total cholesterol (by 10 mg/dL) | −0.034 | −0.11 to 0.046 | 1.02 | 0.96 to 1.07 |
| Triglycerides (by 10 mg/dL) | −0.021 | −0.052 to 0.010 | 1.02 | 0.998 to 1.03 |
| HbA1c* (%) | 0.031 | −0.18 to 0.24 | 1.10 | 0.97 to 1.26 |
| Uric acid (mg/dL) | 0.050 | −0.16 to 0.26 | 1.03 | 0.89 to 1.20 |
| Systolic blood pressure (by 10 mm Hg) | −0.17 | −0.30 to −0.038 | 1.05 | 0.95 to 1.15 |
| ACR (by 10 mg/gCr) | −0.019 | −0.027 to −0.010 | 1.004 | 1.001 to 1.008 |
| eGFR (by 10 mL/min/1.73 m2) | −0.85 | −1.03 to −0.68 | 1.86 | 1.65 to 2.11 |
Calculated by multiple regression analysis as to yearly change of eGFR to identify the baseline risk factors weighting by the square of follow-up period.
Calculated by multiple logistic regression analysis in contradistinction to moderate lowering group (group 2).
*NGSP, National Glycohemoglobin Standardization Program.
ACR, urinary albumin to creatinine ratio; BMI, body mass index; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein.