Clinical characteristics of the subjects for the validation cohort stratified by the severity of coronary artery stenosis (n=228)
| Variables | Normal (n=99) | Mild-to-moderate stenosis (n=95) | Severe stenosis (n=34) | P value | Post hoc analysis | P for trend |
| Age (years) | 53.4±8.2 | 59.1±8.8 | 63.3±10.0 | <0.001 | a, b, c | |
| Male (%) | 43 (49.4) | 80 (77.7) | 24 (82.8) | <0.001 | <0.001 | |
| BMI (kg/m2) | 24.7±3.0 | 25.0±2.8 | 24.1±2.7 | 0.417 | ||
| Systolic blood pressure (mm Hg) | 123.7±15.4 | 125.8±10.1 | 124.4±18.3 | 0.882 | ||
| Comorbidities | ||||||
| Diabetes mellitus (%) | 24 (27.6) | 31 (30.1) | 10 (34.5) | 0.769 | ||
| Hypertension (%) | 17 (19.5) | 27 (26.2) | 13 (44.8) | 0.027 | 0.041 | |
| Dyslipidemia (%) | 12 (13.8) | 16 (15.5) | 9 (31.0) | 0.088 | 0.621 | |
| Laboratory values | ||||||
| HbA1c (%) | 6.3±1.4 | 6.4±1.5 | 6.8±1.9 | 0.336 | ||
| Total cholesterol (mg/dL) | 210.2±44.8 | 206.8±39.5 | 185.2±40.4 | 0.017 | b, c | |
| Triglyceride (mg/dL) | 170.2±242.7 | 167.9±118.2 | 167.0±57.7 | 0.950 | ||
| HDL-C (mg/dL) | 53.7±11.9 | 50.2±12.7 | 45.8±9.2 | 0.003 | b | |
| LDL-C (mg/dL) | 111.8±29.6 | 113.8±33.3 | 109.6±22.2 | 0.890 | ||
| AST (IU/L) | 26.2±8.9 | 24.6±8.0 | 24.7±10.5 | 0.488 | ||
| ALT (IU/L) | 30.6±18.5 | 31.4±20.1 | 21.5±9.2 | 0.012 | b, c | |
| eGFR (mL/min/1.73 m2) | 80.8±15.4 | 74.4±15.2 | 81.6±27.2 | 0.077 | ||
| Albumin-to-creatinine ratio (g/mg) | 11.3±18.7 | 132.0±14.39 | 111.34±442.02 | 0.562 | ||
| hsCRP (mg/dL) | 0.17±0.34 | 0.32±1.15 | 2.30±5.05 | <0.001 | b, c |
Data are presented as the mean±SD. hsCRP was analysed by log transformation.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; eGFR, estimated glomerular filtration rate; HDL-C, high-density lipoprotein cholesterol; hsCRP, high-sensitivity C reactive protein; LDL-C, low-density lipoprotein cholesterol.