Table 2

Statistically significant associations of IgG glycan traits with eGFR change per year

Glycan traitsBasic modelFull model
βP valueβP value
GP4 (FA2)−1.136.17E−03−0.13NS
GP6 (FA2B)−1.387.76E−04−0.766.18E−03
GP8 (A2BG1; FA2[6]G1)1.182.28E−030.61NS
GP9 (FA2[3]G1)1.055.65E−030.44NS
GP14 (FA2G2)1.121.01E−020.49NS
Derived traits
FG2S1/(FG2+FG2S1+FG2S2)−0.27NS−0.742.66E−03
FBStotal/FStotal−1.163.94E−03−0.31NS
FBS2/FS2−1.384.16E−04−0.783.20E−03
FBS2/(FS2+FBS2)−1.212.25E−03−0.745.89E−03
G0n−1.321.84E−03−0.39NS
G1n1.433.51E−040.34NS
Fn0.71NS0.705.70E−03
FG1n/G1n0.80NS0.714.71E−03
FG2n/G2n1.086.09E−030.51NS
FBn−0.73NS−0.724.73E−03
FBG1n/G1n−0.77NS−0.705.24E−03
FBG2n/G2n−1.271.42E−03−0.754.11E−03
FBn/Fn−0.77NS−0.782.20E−03
FBn/Fntotal−0.74NS−0.743.89E−03
  • Basic model: age, sex and their interaction.

  • Full model: smoking, mean arterial pressure, body mass index, HbA1c, duration of type 2 diabetes, non-HDL, HDL.

  • A p value was considered statistically significant for the basic model when p<1.01E−02 and for the full model when p<6.18E−03. Regression coefficient (beta) and p value per association, with FDRα used as cut-off for significance.

  • B, bisection; eGFR, estimated glomerular filtration rate; F, fucose; G, galactose; HDL, high-density lipoprotein; N, neutral; NS, non-significant; S, sialylation.