Values of physical and biochemical examination in two types of rats: LETO and OLETF
| Weeks of age | Strain | Tadalafil | n | Body weight (g) | Systolic blood pressure (mm Hg) | Plasma glucose (mg/dL) | Plasma insulin (pg/mL) | LDL- cholesterol (mg/dL) | Plasma triglyceride (mg/dL) |
| 36 | LETO | 16 | 541.8±15.8 | 201±4 | 165±10 | 5436±164 | 13±1 | 63±4 | |
| OLETF | 16 | 661.5±18.4* | 233±11* | 199±7* | 3713±153* | 24±1* | 179±10* | ||
| 48 | LETO | Vehicle | 8 | 560.1±13.1 | 215±8† | 180±3 | 4778±279* | 14±1 | 69±2 |
| + | 8 | 544.2±16.8 | 217±6† | 179±6 | 4594±135* | 14±1 | 68±3 | ||
| OLETF | Vehicle | 8 | 649.8±21.7‡ | 224±5 | 224±10‡§ | 2906±124‡§ | 28±3‡¶ | 247±17‡§ | |
| + | 8 | 633.1±13.8** | 216±10§ | 215±12**¶ | 2823±143§** | 18±1**†† | 214±9§**†† |
*p<0.01 versus LETO-36w.
†p<0.05 versus LETO-36w.
‡p<0.01 versus LETO-ve-48w.
§p<0.01 versus OLETF-36w.
¶p<0.05 vs OLETF-36w.
**p<0.01 vs LETO-ta-48w.
††p<0.01 versus OLETF-ve-48w.
LDL, low-density lipoprotein; LETO, Long-Evans Tokushima Otsuka; LETO-ta-48w, 48-week-old LETO rats treated with tadalafil for 12 weeks; ; LETO-ve-48w, 48-week-old LETO rats treated with vehicle for 12 weeks; LETO-36w, 36-week-old LETO rats; OLETF, Otsuka Long-Evans Tokushima Fatty; OLETF-ve-48w, 48-week-old OLETF rats treated with vehicle for 12 weeks; OLETF-36w, 36-week-old OLETF rats.