Table 1

Values of physical and biochemical examination in two types of rats: LETO and OLETF

Weeks of ageStrainTadalafilnBody weight (g)Systolic blood pressure (mm Hg)Plasma glucose (mg/dL)Plasma insulin (pg/mL)LDL- cholesterol (mg/dL)Plasma triglyceride (mg/dL)
36LETO16541.8±15.8201±4165±105436±16413±163±4
OLETF16661.5±18.4*233±11*199±7*3713±153*24±1*179±10*
48LETOVehicle8560.1±13.1215±8†180±34778±279*14±169±2
+8544.2±16.8217±6†179±64594±135*14±168±3
OLETFVehicle8649.8±21.7‡224±5224±10‡§2906±124‡§28±3‡¶247±17‡§
+8633.1±13.8**216±10§215±12**¶2823±143§**18±1**††214±9§**††
  • *p<0.01 versus LETO-36w.

  • †p<0.05 versus LETO-36w.

  • ‡p<0.01 versus LETO-ve-48w.

  • §p<0.01 versus OLETF-36w.

  • ¶p<0.05 vs OLETF-36w.

  • **p<0.01 vs LETO-ta-48w.

  • ††p<0.01 versus OLETF-ve-48w.

  • LDL, low-density lipoprotein; LETO, Long-Evans Tokushima Otsuka; LETO-ta-48w, 48-week-old LETO rats treated with tadalafil for 12 weeks; ; LETO-ve-48w, 48-week-old LETO rats treated with vehicle for 12 weeks; LETO-36w, 36-week-old LETO rats; OLETF, Otsuka Long-Evans Tokushima Fatty; OLETF-ve-48w, 48-week-old OLETF rats treated with vehicle for 12 weeks; OLETF-36w, 36-week-old OLETF rats.