Table 2
MR statistical sensitivity analyses
| Outcome (case/control) | MR-Egger | Simple median | Weighted-median | ||||||
| OR (95% CI) | P value | Intercept (95% CI) | P value for intercept |  | OR (95% CI) | P value | OR (95% CI) | P value | |
| CAD (60 801/123 504) | |||||||||
| 53-SNPs | 1.68 (1.22 to 2.32) | 0.002 | 0.002 (−0.006 to 0.009) | 0.67 | 94.6% | 2.02 (1.60 to 2.54) | <0.001 | 1.73 (1.39 to 2.16) | <0.001 |
| 52-SNPs | 2.12 (1.18 to 3.82) | 0.01 | −0.003 (−0.014 to 0.009) | 0.65 | 78.9% | 2.03 (1.59 to 2.57) | <0.001 | 2.09 (1.66 to 2.64) | <0.001 |
| 28-SNPs | 0.94 (0.30 to 2.99) | 0.92 | 0.009 (−0.009 to 0.028) | 0.32 | 9.6% | 1.97 (1.37 to 2.83) | <0.001 | 1.86 (1.30 to 2.67) | 0.001 |
| MI (43 677/128 199) | |||||||||
| 53-SNPs | 1.78 (1.27 to 2.49) | 0.001 | 0.000 (−0.007 to 0.008) | 0.98 | 94.6% | 1.74 (1.36 to 2.23) | <0.001 | 1.76 (1.35 to 2.30) | <0.001 |
| 52-SNPs | 1.87 (1.01 to 3.44) | 0.045 | −0.001(−0.013 to 0.011) | 0.89 | 79.5% | 1.76 (1.35 to 2.29) | <0.001 | 1.97 (1.52 to 2.56) | <0.001 |
| 28-SNPs | 0.80 (0.20 to 3.13) | 0.74 | 0.012 (−0.010 to 0.034) | 0.27 | 8.3% | 2.02 (1.34 to 3.06) | 0.001 | 1.99 (1.32 to 3.02) | 0.001 |
| IS (40 585/406 111) | |||||||||
| 53-SNPs | 0.92 (0.66 to 1.27) | 0.61 | 0.007 (0.000 to 0.053) | 0.053 | 94.7% | 1.39 (1.09 to 1.78) | 0.009 | 1.15 (0.92 to 1.44) | 0.21 |
| 52-SNPs | 1.32 (0.71 to 2.44) | 0.38 | 0.001 (−0.011 to 0.012) | 0.92 | 78.8% | 1.39 (1.09 to 1.78) | 0.009 | 1.39 (1.09 to 1.77) | 0.008 |
| 28-SNPs | 2.07 (0.41 to 10.42) | 0.38 | −0.007 (−0.033 to 0.018) | 0.57 | 0.0% | 1.55 (1.02 to 2.36) | 0.04 | 1.63 (1.08 to 2.48) | 0.02 |
| LAA (34 217/406 111) | |||||||||
| 53-SNPs | 0.97 (0.44 to 2.16) | 0.94 | 0.006 (−0.011 to 0.024) | 0.48 | 94.8% | 1.33 (0.72 to 2.44) | 0.36 | 1.00 (0.59 to 1.72) | 0.99 |
| 52-SNPs | 5.69 (1.30 to 24.78) | 0.02 | −0.025 (−0.053 to 0.003) | 0.08 | 79.1% | 1.33 (0.73 to 2.44) | 0.36 | 1.86 (1.01 to 3.40) | 0.046 |
| 28-SNPs | 6.03 (0.17 to 216.59) | 0.33 | −0.027 (−0.084 to 0.029) | 0.34 | 0.0% | 1.03 (0.38 to 2.78) | 0.95 | 0.90 (0.33 to 2.44) | 0.84 |
| SAO (5386/406 111) | |||||||||
| 53-SNPs | 0.94 (0.45 to 1.96) | 0.87 | 0.017 (0.000 to 0.033) | 0.046 | 94.7% | 2.28 (1.28 to 4.08) | 0.005 | 1.09 (0.66 to 1.81) | 0.74 |
| 52-SNPs | 1.49 (0.35 to 6.27) | 0.59 | 0.008 (−0.019 to 0.036) | 0.55 | 78.8% | 2.56 (1.44 to 4.53) | 0.001 | 2.28 (1.28 to 4.04) | 0.005 |
| 28-SNPs | 14.43 (0.58 to 359.96) | 0.10 | −0.028 (−0.078 to 0.023) | 0.29 | 0.0% | 2.28 (0.90 to 5.75) | 0.08 | 2.24 (0.89 to 5.64) | 0.09 |
| CE (7193/406 111) | |||||||||
| 53-SNPs | 0.71 (0.39 to 1.28) | 0.25 | 0.008 (−0.005 to 0.021) | 0.24 | 94.7% | 0.96 (0.61 to 1.51) | 0.86 | 0.72 (0.46 to 1.14) | 0.16 |
| 52-SNPs | 0.82 (0.26 to 2.60) | 0.74 | 0.005 (−0.017 to 0.027) | 0.65 | 79.2% | 0.97 (0.61 to 1.55) | 0.90 | 1.12 (0.70 to 1.78) | 0.64 |
| 28-SNPs | 0.95 (0.05 to 19.85) | 0.97 | 0.004 (−0.044 to 0.052) | 0.88 | 0.0% | 0.97 (0.45 to 2.11) | 0.94 | 0.98 (0.45 to 2.13) | 0.96 |
CAD, coronary artery disease; CE, cardioembolism; IS, ischemic stroke; LAA, large-artery atherosclerosis; MI, myocardial infarction; MR, Mendelian randomization; SAO, small-artery occlusion; SNP, single nucleotide polymorphism.