Association of VPT, DNS and DN4 scores with B12 deficiency
| Parameters | Non-metformin users | Metformin users | ||||||||
| B12 | B12 | |||||||||
| <200 | 200–300 | >300 | P value | Overall | <200 | 200–300 | >300 | P value | Overall | |
| VPT | ||||||||||
| <15 | 4 (66.6%) | 33 (44.6%) | 65 (33.5%) | <0.0001 | 102 (37.2%) | 7 (29.2%) | 69 (68.3%) | 53 (16.8%) | <0.0001 | 129 (29.3%) |
| 15–25 | 1 (16.7%) | 12 (16.2%) | 21 (10.8%) | 34 (12.4%) | 0 (0%) | 14 (13.9%) | 45 (14.3%) | 59 (13.4%) | ||
| >25 | 1 (16.7%) | 29 (39.2%) | 108 (55.7%) | 138 (50.4%) | 17 (70.8%) | 18 (17.8%) | 217 (68.9%) | 252 (57.3%) | ||
| DNS | ||||||||||
| <1 | 5 (83.3%) | 61 (79.2%) | 116 (62.7%) | 0.001 | 182 (64.2%) | 4 (16%) | 31 (27%) | 76 (18.8%) | 0.137 | 111 (20.4%) |
| ≥1 | 1 (16.7%) | 16 (20.8%) | 69 (37.3%) | 86 (35.8%) | 21 (84%) | 84 (73%) | 328 (81.2%) | 433 (79.6%) | ||
| DN4 | ||||||||||
| <4 | 6 (100%) | 70 (92.1%) | 146 (80.2%) | 0.01 | 222 (84.1%) | 7 (29.2%) | 70 (60.9%) | 175 (43.3%) | <0.0001 | 252 (46.4%) |
| ≥4 | 0 (0%) | 6 (7.9%) | 36 (19.8%) | 42 (15.9%) | 17 (70.8%) | 45 (39.1%) | 229 (56.7%) | 291 (53.6+%) | ||
Data presented as n (%).
χ2 test was applied.
P<0.05 considered to be statistically significant.
DN4, Douleur Neuropathique 4; DNS, Diabetic Neuropathy Symptom; VPT, vibration perception threshold.