Variables | GRS9 quartiles | Total | P value | |||
Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | |||
Participants | 1462 | 1474 | 1496 | 1477 | 5909 | |
Age (years) | 51.6±8.8 | 51.5±8.8 | 51.5±8.6 | 51.3±8.6 | 51.5±8.7 | 0.764 |
Sex (male, %) | 668 (45.7) | 669 (45.4) | 753 (50.3) | 688 (46.6) | 2778 (47.0) | 0.025 |
HTN (n, %) | 195 (13.3) | 178 (12.1) | 171 (11.4) | 173 (11.7) | 717 (12.1) | 0.698 |
BMI (kg/m2) | 24.6±3.1 | 24.3±3.0 | 24.4±3.1 | 24.3±3.1 | 24.4±3.1 | 0.014 |
Waist (cm) | 81.9±10.8 | 81.3±10.4 | 81.5±11.2 | 81.5±10.1 | 81.5±10.6 | 0.380 |
Hip (cm) | 93.2±9.7 | 92.9±8.9 | 92.8±10.2 | 92.8±8.8 | 92.9±9.4 | 0.508 |
SBP (mm Hg) | 123.1±20.9 | 121.8±31.7 | 122.9±32.9 | 123.7±33.0 | 122.1±32.3 | 0.448 |
DBP (mm Hg) | 82.1±13.6 | 81.5±12.6 | 81.7±12.9 | 81.9±12.4 | 81.8±12.9 | 0.588 |
eGFR (mL/min/1.73 m2) | 93.3±12.9 | 93.2±13.1 | 92.9±13.1 | 93.2±12.8 | 93.1±13.0 | 0.816 |
75 g OGTT | ||||||
Fasting glucose (mg/dL) | 86.8±8.4 | 87.3±8.4 | 88.1±8.8 | 88.0±8.6 | 87.6±8.5 | <0.001 |
2-hour glucose (mg/dL) | 120.1±31.4 | 121.8±31.7 | 122.9±32.9 | 123.7±33.0 | 122.1±32.3 | 0.030 |
Impaired fasting glucose (n, %) | 106 (7.3) | 107 (7.3) | 135 (9.0) | 143 (9.7) | 491 (8.3) | 0.030 |
Impaired glucose tolerance (n, %) | 351 (24.0) | 397 (26.9) | 424 (28.3) | 423 (28.6) | 1595 (27.0) | <0.001 |
HbA1c (%) | 5.5±0.3 | 5.5±0.4 | 5.5±0.3 | 5.6±0.3 | 5.5±0.3 | 0.030 |
Total cholesterol (mg/dL) | 188.6±33.9 | 189.4±33.7 | 190.9±35.0 | 188.6±33.9 | 189.4±34.1 | 0.201 |
HDL cholesterol (mg/dL) | 44.8±10.1 | 45.3±10.0 | 45.2±10.5 | 44.8±9.8 | 45.0±10.1 | 0.402 |
Triglyceride (mg/dL) | 152.3±83.7 | 152.4±96.9 | 157.0±102.1 | 154.9±98.3 | 154.2±95.6 | 0.480 |
Albumin (g/dL) | 4.5±0.3 | 4.5±0.3 | 4.5±0.2 | 4.5±0.4 | 4.5±0.3 | 0.477 |
New DM event (n, %) | 141 (9.6) | 155 (10.5) | 189 (12.6) | 150 (10.2) | 635 (10.7) | 0.045 |
CKD event (n, %) | 115 (7.9) | 127 (8.6) | 120 (8.0) | 128 (8.7) | 490 (8.3) | 0.809 |
BMI, body mass index; CKD, chronic kidney disease; DBP, diastolic blood pressure; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; GRS9, 9 genetic risk score associated with fasting glucose; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; HTN, hypertension; OGTT, oral glucose tolerance test; SBP, systolic blood pressure.