Table 4

Subjects’ clinical characteristics by FN3K genotype group; for continuous data, values are mean±SD

ParameterA genotypeB genotypeC genotypeE genotypeOthers
n82311830
Age (years)74±8C,Others69±864±7E71±768±7
Gender, M/F4/48/157/45/317/13
Diabetes duration (years)12.4±4.014.6±4.515.7±3.913.1±4.615.1±4.2
BMI (kg/m2)31±530±631±529±430±5
Waist circumference (cm)102±8103±12105±13100±7101±11
Systolic blood pressure (mm Hg)135±12135±12138±13139±12137±10
Diastolic blood pressure (mm Hg)79±680±979±780±1081±7
DCCT-HbA1c (%)7.2±0.77.6±1.07.3±0.57.7±1.17.2±0.7
IFCC-HbA1c (mmol/mol)54.8±7.659.3±11.356.0±6.259.6±14.054.9±6.9
Total cholesterol (mg/dL)181±33180±48158±28188±23179±32
HDL cholesterol (mg/dL)56±2057±1855±1047±950±14
Triglycerides (mg/dL)131±57105±4796±36131±41128±61
Microalbuminuria, yes/no8/03/203/83/57/23
Albuminuria (mg/g)5±431±6522±2119±1928±34
Creatininemia (mg/dL)0.9±0.30.8±0.20.9±0.21.0±0.20.8±0.2
Glomerular filtration rate (mL/min)77±1684±2082±1771±1489±21E
Homocysteine (µmol/L)17±316±518±818±715±5
Vitamin A (µg/dL)56±1551±1545±1052±1052±17
Vitamin E (mg/dL)1.5±0.3B1.3±0.31.3±0.31.3±0.21.3±0.3
Cerebral macroangiopathy, yes/no4/416/75/65/320/10
Coronary heart disease, yes/no0/83/201/100/80/30
Retinopathy, yes/no0/85/185/61/711/19
Peripheral artery disease, yes/no0/83/201/102/85/25
  • Superscript letters indicate significant differences between respective genotype groups.

  • BMI, body mass index; DCCT-HbA1c, HbA1c according to Diabetes Control and Complications Trial units; F, female; FN3K, fructosamine-3-kinase; HDL, high-density lipoprotein; IFCC-HbA1c, HbA1c according to International Federation of Clinical Chemistry units; M, male.