Table 2

Genotypes and allele frequencies of FN3K genetic variants identified in patients with T2DM

Promoter region variantsT2DM (n=80)Exon/intron variantsT2DM (n=80)
c.-385 A>G (rs3859206)AA0.31c.2 T>ATT0.99
AG0.54AT0.01
GG0.15AA/
G-allele0.42A-allele0.01
c.-232 A>T (rs 2256339)AA0.27c.187 A>C (rs2253149)AA/
AT0.58AC/
TT0.15CC1
T-allele0.44C-allele0.01
c.-421 C>TCC0.99IVS2-27 A>TAA0.99
CT0.01AT0.01
TT/TT/
T-allele0.01T-allele0.01
c.-429delATCGGAG+/+0.99IVS2 +26 A>G (rs2253132)AA1
+/del0.01AG/
del/del/GG/
del0.01A-allele0.01
IVS2 +31 A>T (rs2253131)AA/
AT0.19
TT0.81
A-allele0.09
c.465 G>AGG0.99
AG0.01
AA/
A-allele0.01
IVS4-9delTTG (rs72318398)+/+0.74
+/del0.25
del/del0.01
del0.14
c.900 C>G (rs1056534)CC0.15
GC0.48
GG0.37
C-allele0.39
c.906 C>T (rs149413139)CC0.98
CT0.03
TT/
T-allele0.01
  • Values for genotypes and rare alleles are frequencies.

  • rs ID: http://www.ncbi.nlm.nih.gov/snp/.

  • β€˜+’ symbol indicates the wild-type allele; β€˜del’ denotes the allele characterized by the deletion.

  • FN3K, fructosamine-3-kinase; rs, RefSNP; T2DM, type 2 diabetes mellitus.