Baseline clinical characteristics stratified by eGFR declining speed
| Increasing (n=66) | Control (n=81) | Decreasing (n=230) | Total | Inc vs Cont | Dec vs Cont | |||||||||
| Median | 25 | 75 | Median | 25 | 75 | Median | 25 | 75 | Median | 25 | 75 | P value | P value | |
| Age (years old) | 56 | 47 | 63 | 60 | 53 | 66 | 60 | 50 | 67 | 59 | 51 | 66 | <0.05 | |
| Gender (male) | 69.7% | 72.8% | 71.7% | 71.6% | ||||||||||
| BMI | 22.7 | 20.8 | 25.4 | 23.4 | 21.6 | 25.8 | 23.0 | 21.2 | 25.5 | 23.0 | 21.2 | 25.6 | ||
| SysBP (mm Hg) | 134 | 123 | 146 | 140 | 130 | 155 | 148 | 138 | 162 | 142 | 132 | 160 | <0.05 | <0.01 |
| DiaBP (mm Hg) | 73 | 70 | 84 | 80 | 70 | 87 | 80 | 72 | 90 | 80 | 70 | 88 | ||
| Hb (g/dL) | 13.4 | 11.9 | 15.2 | 12.8 | 11.3 | 14.4 | 11.6 | 10.0 | 13.2 | 12.2 | 10.5 | 13.9 | <0.01 | |
| eGFR (mL/min/1.73 m2/year) | 53.9 | 38.8 | 70.6 | 50.2 | 31.7 | 65.5 | 47.3 | 35.0 | 66.0 | 49.1 | 35.0 | 66.4 | ||
| UA (mg/dL) | 6.0 | 5.2 | 7.4 | 6.7 | 5.8 | 7.5 | 6.5 | 5.7 | 7.6 | 6.5 | 5.6 | 7.6 | ||
| TP (g/dL) | 7.0 | 6.5 | 7.7 | 6.8 | 6.1 | 7.1 | 6.0 | 5.4 | 6.8 | 6.3 | 5.6 | 7.0 | <0.01 | |
| Alb (g/dL) | 3.8 | 3.4 | 4.3 | 3.6 | 2.9 | 4.0 | 3.0 | 2.5 | 3.5 | 3.2 | 2.6 | 3.7 | <0.01 | |
| HbA1c (%) | 7.6 | 6.5 | 8.8 | 7.2 | 6.4 | 8.5 | 7.0 | 6.0 | 8.9 | 7.2 | 6.2 | 8.8 | ||
| Tcho (mg/dL) | 193 | 159 | 226 | 194 | 165 | 229 | 211 | 179 | 256 | 206 | 175 | 244 | <0.01 | |
| LDL (mg/dL) | 120 | 102 | 173 | 135 | 106 | 168 | 133 | 102 | 160 | 132 | 102 | 162 | ||
| TG (mg/dL) | 156 | 103 | 219 | 158 | 107 | 195 | 153 | 114 | 210 | 154 | 110 | 207 | ||
| Ualb (g/day) | 0.4 | 0.1 | 0.9 | 0.6 | 0.2 | 1.3 | 2.0 | 0.9 | 3.4 | 1.2 | 0.5 | 2.6 | <0.05 | <0.01 |
| UOB | 14.5% | 20.7% | 42.0% | 32.7% | ||||||||||
| ACEI | 25.0% | 32.5% | 33.6% | 32.3% | ||||||||||
| ARB | 21.4% | 55.0% | 53.7% | 49.8% | <0.01 | |||||||||
| RAS | 46.4% | 87.5% | 87.2% | 82.0% | <0.05 | |||||||||
| CCB | 50.0% | 60.0% | 49.7% | 51.6% | ||||||||||
| Lipid | 17.9% | 20.0% | 28.2% | 25.3% | ||||||||||
Data are median (25th, 75th percentile) or percentage unless otherwise indicated.
ACEI, ACE inhibitor; Alb, albumin; ARB, angiotensin II receptor blocker; BMI, body mass index; CCB, calcium channel blocker; Cont, control group; Dec, eGFR declining group; DiaBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; Hb, hemoglobin; Inc, eGFR increasing group; LDL, low-density-lipoprotein cholesterol; lipid, lipid-lowering agent; RAS, renin–angiotensin–aldosterone system blocker; SysBP, systolic blood pressure; Tcho, total cholesterol; TG, triglyceride; TP, total protein; UA, uric acid; UAlb, urinary albumin; UOB, urinary occult blood.