Table 2

Association of blood glucose group with progression to critical cases/death from non-critical cases at admission in patients with COVID-19 and with in-hospital mortality in critical cases of COVID-19 in multivariable Cox regression model*

Variables	Non-critical patients		Critical patients†
Variables	Adjusted HR (95% CI)	P value	Adjusted HR (95% CI)	P value
Admission glucose group
Normal (<6.1)	1.00		1.00
Hyperglycemia (≥6.1)	1.30 (1.03 to 1.63)	0.026	1.84 (1.14 to 2.98)	0.013
Gender (female)	0.86 (0.70 to 1.06)	0.157	0.43 (0.28 to 0.66)	<0.001
Age (year)	1.02 (1.01 to 1.02)	<0.001	1.03 (1.02 to 1.05)	<0.001
Diabetes	1.03 (0.72 to 1.48)	0.851	1.26 (0.72 to 2.22)	0.415
Hypertension	1.21 (0.95 to 1.53)	0.125	0.80 (0.52 to 1.22)	0.293
Smoking history	1.17 (0.88 to 1.55)	0.275	1.36 (0.89 to 2.08)	0.162
Insulin treatment	1.09 (0.78 to 1.51)	0.616	0.94 (0.57 to 1.54)	0.807
Systemic glucocorticoids	1.77 (1.40 to 2.22)	<0.001	4.47 (2.41 to 8.30)	<0.001
Chronic kidney disease	2.24 (1.14 to 4.41)	0.019	0.50 (0.14 to 1.78)	0.284
Chronic obstructive pulmonary disease	0.96 (0.55 to 1.66)	0.885	0.58 (0.26 to 1.28)	0.179
Cancer	0.76 (0.33 to 1.75)	0.519	0.66 (0.18 to 2.43)	0.534
Admission white cell counts	1.10 (1.07 to 1.13)	<0.001	1.10 (1.06 to 1.14)	<0.001
Admission lymphocyte counts	0.55 (0.42 to 0.71)	<0.001	0.63 (0.37 to 1.07)	0.090
Admission D-Dimer	1.06 (1.03 to 1.09)	<0.001	1.02 (0.99 to 1.04)	0.267
Admission AST	1.00 (1.00 to 1.00)	0.157	1.00 (1.00 to 1.01)	0.106
Admission ALT	1.00 (0.99 to 1.00)	0.684	0.99 (0.98 to 1.00)	0.185
Admission creatinine	1.00 (1.00 to 1.00)	0.102	1.00 (1.00 to 1.00)	<0.001

*Multivariable Cox analysis was adjusted for all available factors in baseline table.
†The glucose-associated indices of critical cases were analyzed based on the blood glucose concentration after diagnosis of critical case.
ALT, alanine aminotransferase; AST, aspartate aminotransferase.