Comparison of NAFLD concomitant rates under different glucose metabolism status between South and North group
| No of NAFLD | NAFLD prevalence (%) | OR (95% CI) | ||||
| Unadjusted | Model 1 | Model 2 | Model 3 | |||
| All participants (n=2420) | ||||||
| Total | 1050 | 43.39 | – | – | – | |
| South | 545 | 35.95 | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) |
| North | 505 | 55.86 | 2.25 (1.91 to 2.67) | 2.23 (1.87 to 2.68) | 3.56 (2.84–4.47) | 3.09 (2.45–3.90) |
| P value | <0.001 | <0.001 | <0.001 | <0.001 | ||
| NGT (n=750) | ||||||
| Total | 175 | 23.33 | – | – | – | – |
| South | 75 | 16.23 | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) |
| North | 100 | 34.72 | 2.74 (1.94 to 3.89) | 3.05 (2.06 to 4.55) | 4.45 (2.79–7.19) | 4.15 (2.52–6.95) |
| P value | <0.001 | <0.001 | <0.001 | <0.001 | ||
| IGR (n=425) | ||||||
| Total | 187 | 44.00 | – | – | – | – |
| South | 96 | 34.66 | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) |
| North | 91 | 61.49 | 3.01 (2.00 to 4.57) | 2.90 (1.85 to 4.60) | 5.54 (3.17–9.94) | 4.45 (2.49–8.17) |
| P value | <0.001 | <0.001 | <0.001 | <0.001 | ||
| T2DM (n=1245) | ||||||
| Total | 688 | 55.26 | – | – | – | – |
| South | 374 | 48.13 | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) |
| North | 314 | 67.09 | 2.20 (1.73 to 2.79) | 1.96 (1.53 to 2.53) | 2.91 (2.14–3.97) | 2.54 (1.86–3.50) |
| P value | <0.001 | <0.001 | <0.001 | <0.001 | ||
Multivariate logistic regression models were gradually adjusted for: Model 1 was adjusted for age, gender, alcohol drinking and cigarette smoking. Model 2 was adjusted for BMI, WC, FBG, SBP, TG, TC, LDL-c, HDL-c, UA and statins treatment in addition to factors included in model 1. Model 3 was adjusted for ALT, AST, GGT in addition to factors included in model 2.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; FBG, fasting blood glucose; GGT, gamma-glutamyl transferase; HDL-c, high-density lipoprotein cholesterol; IGR, impaired glucose regulation; LDL-c, low-density lipoprotein cholesterol; NAFLD, non-alcoholic fatty liver disease; NGT, normal glucose tolerance; SBP, systolic blood pressure; TC, total cholesterol; T2DM, type 2 diabetes mellitus; TG, triglyceride; UA, uric acid; WC, waist circumference.