Table 3

Association between CRP Z-scores and microvascular/macrovascular dysfunction in participants with CRP concentrations ≤10 mg/L

	Whole cohort (n=4962)			Non-diabetes group (n=4430)			Diabetes group (n=532)
	OR (95% CI), p value			OR (95% CI), p value			OR (95% CI), p value
	Model 1	Model 2	Model 3	Model 1	Model 2	Model 3	Model 1	Model 2	Model 3
PAD	1.18 (1.07 to 1.32), 0.002	1.14 (1.03 to 1.28), 0.014	1.06 (0.94 to 1.19), 0.349	1.18 (1.05 to 1.33), 0.004	1.15 (1.02 to 1.29), 0.024	1.06 (0.93 to 1.21), 0.372	1.21 (0.92 to 1.60), 0.177	1.16 (0.87 to 1.55), 0.321	1.05 (0.75 to 1.47), 0.785
Nephropathy	1.95 (1.43 to 2.67), <0.001	1.67 (1.20 to 2.31), 0.002	1.43 (1.00 to 2.06), 0.051	1.72 (1.20 to 2.47), 0.003	1.44 (0.98 to 2.10), 0.061	1.32 (0.87 to 1.99), 0.194	1.88 (0.96 to 3.69), 0.065	2.07 (1.02 to 4.18), 0.044	1.69 (0.77 to 3.71), 0.189
Albuminuria	2.04 (1.45 to 2.88), <0.001	1.85 (1.31 to 2.63), 0.001	1.61 (1.09 to 2.38), 0.017	1.95 (1.32 to 2.89), 0.001	1.74 (1.16 to 2.59), 0.007	1.61 (1.03 to 2.51), 0.035	1.53 (0.73 to 3.24), 0.262	1.64 (0.75 to 3.59), 0.212	1.42 (0.59 to 3.40), 0.435
Low eGFR	1.30 (0.71 to 2.37), 0.397	0.95 (0.49 to 1.85), 0.890	0.74 (0.36 to 1.50), 0.400	1.00 (0.47 to 2.10), 0.993	0.68 (0.30 to 1.55), 0.363	0.61 (0.25 to 1.45), 0.260	1.56 (0.51 to 4.78), 0.433	1.96 (0.57 to 6.69), 0.283	1.20 (0.30 to 4.75), 0.796

Whole group analyses: model 1 was unadjusted; model 2 adjusted for age and sex; model 3 adjusted additionally for site of residence, smoking, BMI, systolic blood pressure, diabetes and LDL-cholesterol.
Subgroup (diabetes and non-diabetes) analyses: model 1 was unadjusted; model 2 adjusted for age and sex; model 3 adjusted additionally for site of residence, smoking, BMI, systolic blood pressure, and LDL-cholesterol.
BMI, body mass index; CRP, C reactive protein; eGFR, estimated glomerular filtration rate; LDL, low-density lipoprotein; PAD, peripheral artery disease.