Table 2

Crude and adjusted HR of mortality among patients with diabetes with major lower-extremity amputation

%HR95% CIHRagg95% CIP value
Gender
 Male66.31.001.00
 Female33.71.170.88 to 1.580.950.70 to 1.310.796
Age
 35–547.01.001.00
 55–6416.11.000.53 to 1.871.070.56 to 2.030.845
 65–7434.21.580.89 to 2.821.580.87 to 2.870.134
 75+42.71.971.12 to 3.471.911.05 to 3.480.035
Education level
 Low48.21.001.00
 Medium35.20.810.60 to 1.110.980.70 to 1.370.902
 High16.60.700.47 to 1.040.920.61 to 1.400.711
Comorbidities*
 Vasculopathy41.70.910.69 to 1.220.910.65 to 1.280.580
 Neuropathy5.00.460.24 to 0.880.510.26 to 0.980.043
 Cardiovascular diseases†66.80.970.72 to 1.300.870.59 to 1.270.458
 Cardiovascular risk factors‡45.20.940.71 to 1.240.870.63 to 1.200.398
 Neoplasm6.51.100.62 to 1.931.170.65 to 2.080.605
 Chronic renal diseases27.11.641.22 to 2.221.681.20 to 2.360.002
Drug consumption§
 At least two antidepressant drug prescriptions20.11.441.01 to 2.041.451.01 to 2.080.044
  • *In the 24 months preceding the index date.

  • †Ischemic disease, heart failure, cerebrovascular disease, vascular disease, previous cardiac revascularization, and cerebrovascular revascularization.

  • ‡Lipid metabolism disorders and hypertension.

  • §In the 6 months preceding the index date.