Crude and adjusted HR of mortality among patients with diabetes with minor lower-extremity amputation
| % | HR | 95% CI | HRagg | 95% CI | P value | |
| Gender | ||||||
| Male | 69.7 | 1.00 | 1.00 | |||
| Female | 30.3 | 1.24 | 0.98 to 1.57 | 1.07 | 0.83 to 1.38 | 0.609 |
| Age | ||||||
| 35–54 | 8.4 | 1.00 | 1.00 | |||
| 55–64 | 15.9 | 1.20 | 0.75 to 1.91 | 1.20 | 0.75 to 1.92 | 0.446 |
| 65–74 | 33.4 | 2.05 | 1.35 to 3.13 | 1.88 | 1.22 to 2.90 | 0.004 |
| 75+ | 42.2 | 4.25 | 2.81 to 6.42 | 3.58 | 2.31 to 5.55 | 0.000 |
| Education level | ||||||
| Low | 47.8 | 1.00 | 1.00 | |||
| Medium | 34.7 | 0.57 | 0.45 to 0.73 | 0.87 | 0.67 to 1.14 | 0.308 |
| High | 17.5 | 0.55 | 0.41 to 0.75 | 0.90 | 0.65 to 1.26 | 0.555 |
| Comorbidities* | ||||||
| Vasculopathy | 38.1 | 1.11 | 0.88 to 1.39 | 0.82 | 0.63 to 1.06 | 0.130 |
| Neuropathy | 6.6 | 0.97 | 0.62 to 1.51 | 0.79 | 0.50 to 1.26 | 0.322 |
| Cardiovascular diseases† | 68.1 | 1.96 | 1.55 to 2.48 | 1.51 | 1.13 to 2.00 | 0.005 |
| Cardiovascular risk factors‡ | 42.8 | 1.37 | 1.10 to 1.71 | 0.90 | 0.69 to 1.17 | 0.430 |
| Neoplasm | 6.9 | 1.77 | 1.14 to 2.74 | 1.28 | 0.82 to 2.00 | 0.283 |
| Chronic renal diseases | 30.9 | 2.35 | 1.87 to 2.96 | 2.03 | 1.58 to 2.61 | 0.000 |
| Drug consumption§ | ||||||
| At least two antidepressant drug prescriptions | 15.6 | 1.50 | 1.11 to 2.03 | 1.27 | 0.94 to 1.73 | 0.124 |
*In the 24 months preceding the index date.
†Ischemic disease, heart failure, cerebrovascular disease, vascular disease, previous cardiac revascularization, and cerebrovascular revascularization.
‡Lipid metabolism disorders and hypertension.
§In the 6 months preceding the index date.