Table 3

Crude and adjusted HR of mortality among patients with diabetes with minor lower-extremity amputation

%HR95% CIHRagg95% CIP value
Gender
 Male69.71.001.00
 Female30.31.240.98 to 1.571.070.83 to 1.380.609
Age
 35–548.41.001.00
 55–6415.91.200.75 to 1.911.200.75 to 1.920.446
 65–7433.42.051.35 to 3.131.881.22 to 2.900.004
 75+42.24.252.81 to 6.423.582.31 to 5.550.000
Education level
 Low47.81.001.00
 Medium34.70.570.45 to 0.730.870.67 to 1.140.308
 High17.50.550.41 to 0.750.900.65 to 1.260.555
Comorbidities*
 Vasculopathy38.11.110.88 to 1.390.820.63 to 1.060.130
 Neuropathy6.60.970.62 to 1.510.790.50 to 1.260.322
 Cardiovascular diseases†68.11.961.55 to 2.481.511.13 to 2.000.005
 Cardiovascular risk factors‡42.81.371.10 to 1.710.900.69 to 1.170.430
 Neoplasm6.91.771.14 to 2.741.280.82 to 2.000.283
 Chronic renal diseases30.92.351.87 to 2.962.031.58 to 2.610.000
Drug consumption§
 At least two antidepressant drug prescriptions15.61.501.11 to 2.031.270.94 to 1.730.124
  • *In the 24 months preceding the index date.

  • †Ischemic disease, heart failure, cerebrovascular disease, vascular disease, previous cardiac revascularization, and cerebrovascular revascularization.

  • ‡Lipid metabolism disorders and hypertension.

  • §In the 6 months preceding the index date.