Variable | Model 1 (partially adjusted) | Model 2 (+VAT, deep SAT, superficial SAT) | ||
β (SE) | P value* | β (SE) | P value* | |
Systolic BP | 0.83 (0.35) | 0.0186 | 0.84 (0.35) | 0.0184 |
Log-fasting insulin | 0.08 (0.02) | 1.75E−5 | 0.08 (0.02) | 1.96E−5 |
Log-HOMA-IR | 0.08 (0.02) | 3.79E−5 | 0.08 (0.02) | 4.19E−5 |
Log-WBISI | −0.10 (0.02) | 5.70E−7 | −0.10 (0.02) | 6.71E−7 |
Log-DI | −0.06 (0.03) | 0.0206 | −0.06 (0.03) | 0.0219 |
Log-ALT | 0.09 (0.02) | 7.78E−6 | 0.09 (0.02) | 7.77E−6 |
Log-triglycerides | 0.05 (0.02) | 0.0034 | 0.05 (0.02) | 0.0036 |
HDL | −0.41 (0.37) | 0.2705 | −0.42 (0.37) | 0.2617 |
P values meeting this threshold are indicated in bold.
*Model 1 was adjusted for age (years), sex, race/ethnicity, and BMI z-score. Model 2 was also adjusted for log-VAT ratio, log-deep SAT ratio, and log-superficial SAT ratio. Hepatic fat was square root-transformed prior to analysis. Significance was set at Bonferroni-corrected p<0.00625 (0.05/8 tests).
ALT, alanine aminotransferase; BMI, body mass index; BP, blood pressure; DI, disposition index; HDL, high-density lipoprotein; HOMA-IR, homeostatic model assessment of insulin resistance; SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue; WBISI, whole body insulin sensitivity index.