Table 4

Univariate Pearson’s correlations between absolute change in glycemic variables and inflammation markers, and vascular health variables between baseline and 12 months

VariableHbA1c1.5-AGGlucose meanGlucose SDGlucose CVGlucose TIRhs-CRP
Carotid-femoral PWV0.032−0.235−0.1320.0800.155−0.3230.361 (p=0.061)
Carotid-radial PWV0.1170.0960.066−0.0150.026−0.476* (p=0.022)0.314 (p=0.062)
Carotid IMT0.0070.390−0.1380.2790.3350.189−0.193
Carotid compliance−0.1990.178−0.3590.0200.0610.2670.099
Carotid stiffness0.131−0.2520.3180.1120.025−0.109−0.140
Femoral IMT−0.282−0.103−0.0830.0940.1050.171−0.095
Systolic BP−0.1840.2010.001−0.253−0.148−0.0090.139
Diastolic BP0.1840.157−0.137−0.1000.038−0.2630.391* (p=0.020)
Pulse pressure−0.2860.1240.065−0.168−0.1580.168−0.368* (p=0.029)
  • CGM absolute change data available for 22 patients with T1D (9 intervention and 13 controls), glucose mean is mean glucose during CGM, glucose SD is SD of glucose variability during CGM, glucose CV is coefficient of variation (SD/mean) during CGM and glucose TIR is proportion of time glucose between 3.9 and 10.0 mmol/L during CGM.

  • *P<0.05.

  • 1.5-AG, 1.5-anhydroglucitol; BP, blood pressure; CGM, continuous glucose monitoring; HbA1c, hemoglobin A1c; hs-CRP, high-sensitivity C reactive protein; IMT, intima-media thickness; PWV, pulse wave velocity; T1D, type 1 diabetes; TIR, time-in-range.