Table 2

Adjusted OR (95% CI) for the associations of GDM risk with quartiles of adipokines at gestational weeks 10–14 and 15–26

GDM cases (n)Controls (n)10–14 GWs multivariable15–26 GWs multivariable
Model IModel II*Model IModel II *
FABP4
Q1:11541.001.001.001.00
Q2:27532.38 (1.05 to 5.43)2.97 (1.17 to 7.53)5.99 (1.88 to 19.1)5.10 (1.37 to 19.0)
Q3:31543.14 (1.36 to 7.22)3.74 (1.46 to 9.57)7.42 (2.39 to 23.0)8.35 (2.28 to 30.6)
Q4:35533.79 (1.63 to 8.85)4.87 (1.84 to 12.9)11.8 (3.57 to 38.9)11.0 (2.85 to 42.7)
P for trend0.005<0.00010.0040.001
Chemerin
Q1:9531.001.001.001.00
Q2:33533.81 (1.56 to 9.29)3.62 (1.47 to 8.91)1.59 (0.63 to 4.02)1.26 (0.48 to 3.33)
Q3:22532.95 (1.14 to 7.59)2.81 (1.07 to 7.36)2.01 (0.77 to 5.21)1.63 (0.59 to 4.53)
Q4:39535.44 (2.05 to 14.4)4.89 (1.83 to 13.1)4.90 (1.97 to 12.2)4.92 (1.88 to 12.9)
P for trend0.003<0.00010.007<0.0001
IL-6
Q1:6411.001.001.001.00
Q2:16403.26 (1.06 to 10.0)3.74 (1.17 to 12.0)1.62 (0.61 to 4.32)1.75 (0.58 to 5.28)
Q3:23414.01 (1.40 to 11.5)3.77 (1.31 to 10.9)2.34 (0.89 to 6.13)2.40 (0.81 to 7.08)
Q4:35407.53 (2.53 to 22.4)9.44 (2.92 to 30.5)3.31 (1.33 to 8.24)3.44 (1.28 to 9.28)
P for trend<0.00010.007<0.0010.01
Leptin
Q1:18541.001.001.001.00
Q2:10530.65 (0.27 to 1.55)0.60 (0.24 to 1.49)0.83 (0.36 to 1.90)0.85 (0.36 to 2.00)
Q3:28542.01 (0.90 to 4.49)1.86 (0.80 to 4.31)1.54 (0.67 to 3.56)1.44 (0.59 to 3.50)
Q4:48533.56 (1.66 to 7.64)3.39 (1.52 to 7.55)3.13 (1.43 to 6.88)3.45 (1.43 to 8.32)
P for trend<0.00010.001<0.00010.001
sOB-R
Q1:56541.001.001.001.00
Q2:21530.43 (0.22 to 0.81)0.37 (0.19 to 0.74)0.25 (0.12 to 0.55)0.20 (0.09 to 0.48)
Q3:14540.31 (0.16 to 0.63)0.28 (0.13 to 0.59)0.17 (0.07 to 0.40)0.11 (0.04 to 0.31)
Q4:13530.23 (0.11 to 0.50)0.24 (0.11 to 0.52)0.15 (0.06 to 0.35)0.14 (0.06 to 0.33)
P for trend<0.0001<0.0001<0.0001<0.0001
Adiponectin
Q1:43541.001.001.001.00
Q2:29530.59 (0.31 to 1.14)0.63 (0.32 to 1.25)0.47 (0.24 to 0.92)0.52 (0.25 to 1.07)
Q3:24540.51 (0.25 to 1.03)0.45 (0.22 to 0.95)0.26 (0.12 to 0.57)0.26 (0.11 to 0.59)
Q4:8530.14 (0.05 to 0.34)0.13 (0.05 to 0.35)0.17 (0.07 to 0.42)0.15 (0.06 to 0.40)
P for trend<0.0001<0.0001<0.0001<0.0001
HMW-adiponectin
Q1:45541.001.001.001.00
Q2:30530.59 (0.31 to 1.12)0.56 (0.28 to 1.08)0.59 (0.30 to 1.17)0.71 (0.34 to 1.51)
Q3:18540.34 (0.16 to 0.70)0.31 (0.14 to 0.66)0.26 (0.12 to 0.55)0.25 (0.11 to 0.58)
Q4:11530.20 (0.09 to 0.46)0.20 (0.08 to 0.48)0.20 (0.08 to 0.48)0.20 (0.08 to 0.50)
P for trend<0.0001<0.0001<0.0001<0.0001
Omentin-1
Q1:24541.001.001.001.00
Q2:37531.63 (0.79 to 3.35)1.69 (0.80 to 3.58)1.25 (0.63 to 2.45)1.39 (0.69 to 2.79)
Q3:19540.71 (0.32 to 1.57)0.77 (0.33 to 1.79)0.71 (0.33 to 1.53)0.89 (0.40 to 2.01)
Q4:24531.00 (0.44 to 2.25)0.95 (0.40 to 2.26)0.80 (0.36 to 1.77)0.80 (0.35 to 1.87)
P for trend0.470.370.440.44
Vaspin
Q1:19521.001.001.001.00
Q2:22521.25 (0.58 to 2.71)1.66 (0.72 to 3.81)1.26 (0.59 to 2.67)1.17 (0.52 to 2.62)
Q3:39522.13 (1.04 to 4.37)2.37 (1.09 to 5.16)1.49 (0.73 to 3.05)1.67 (0.78 to 3.55)
Q4:22511.21 (0.58 to 2.52)1.50 (0.70 to 3.22)1.63 (0.78 to 3.39)1.92 (0.87 to 4.26)
P for trend0.960.230.710.09
RBP4
Q1:22541.001.001.001.00
Q2:27531.27 (0.64 to 2.55)1.31 (0.63 to 2.69)1.09 (0.54 to 2.22)1.29 (0.60 to 2.79)
Q3:22541.00 (0.48 to 2.10)1.13 (0.52 to 2.45)1.14 (0.55 to 2.36)1.28 (0.58 to 2.83)
Q4:33531.54 (0.78 to 3.03)1.69 (0.83 to 3.45)0.85 (0.40 to 1.80)0.99 (0.44 to 2.28)
P for trend0.280.650.180.91
  • Model I adjusted for matching factors matched within a range (maternal age and gestational week of blood collection).

  • *Model II further adjusted for parity, family history of diabetes, and parity.

  • FABP4, fatty acid binding protein-4; GDM, gestational diabetes mellitus; GW, gestational week; HMW-adiponectin, high-molecular weight-adiponectin; IL-6, interleukin-6; Q, quartile; RBP4, retinol binding protein-4; sOB-R, soluble leptin receptor.