Radius | Tibia | |||
Coef. (95% CI) | P value | Coef. (95% CI) | P value | |
Bone strength | ||||
Failure load, N | −390.6 (−621.2 to −159.9) | 0.001 | −891.9 (−1321 to −462.9) | <0.001 |
Geometry | ||||
Total bone area, mm2 | −12.4 (−24.2 to −0.6) | 0.04 | −23.3 (−57.3 to 10.7) | 0.18 |
Cortical area, mm2 | −4.3 (−8.3 to −0.2) | 0.04 | −6.8 (−12.6 to −1.0) | 0.02 |
Tb area, mm2 | −8.1 (−20.5 to 4.3) | 0.20 | −16.4 (−51.3 to 18.5) | 0.35 |
Volumetric density | ||||
Total vBMD, mg/cm3 | −14.0 (−38.2 to 10.2) | 0.26 | −17.7 (−33.9 to −1.6) | 0.03 |
Cortical vBMD, mg/cm3 | −5.6 (−27.5 to 16.3) | 0.61 | −8.1 (−26.6 to 10.3) | 0.39 |
Tb vBMD, mg/cm3 | −18.8 (−30.9 to −6.8) | 0.002 | −16.7 (−26.3 to −7.1) | 0.001 |
Microarchitecture | ||||
Tb bone volume fraction | −0.016 (−0.026 to −0.006) | 0.002 | −0.014 (−0.022 to −0.006) | 0.001 |
Tb thickness, mm | −0.001 (−0.005 to 0.003) | 0.59 | −0.004 (−0.009 to 0.001) | 0.09 |
Tb numbers, 1/mm | −0.17 (−0.26 to −0.07) | <0.001 | −0.09 (−0.17 to −0.00) | 0.04 |
Tb inhomogeneity | 0.032 (0.012 to 0.051) | 0.002 | 0.018 (0.002 to 0.035) | 0.03 |
Cortical thickness, mm | −0.051 (−0.141 to 0.039) | 0.27 | −0.056 (−0.138 to 0.027) | 0.19 |
Cortical porosity, % | 0.005 (−0.001 to 0.011) | 0.10 | 0.004 (−0.003 to 0.012) | 0.24 |
Statistical significance (p<0.05) is highlighted in bold.
Unadjusted data is available as an online supplemental file.
*Adjusted for age, sex, height and body mass index.
HR-pQCT, high-resolution peripheral quantitative CT; Tb, trabecular bone; vBMD, volumetric bone mineral density.