Radius | Tibia | |||
Coef. (95% CI) | P value | Coef. (95% CI) | P value | |
Bone strength | ||||
Failure load, N | −3.7 (−15.6 to 8.2) | 0.54 | −26.7 (−52.7 to −0.7) | 0.04 |
Geometry | ||||
Total bone area, mm2 | −0.45 (−1.21 to 0.32) | 0.2 | −0.8 (−2.9 to 1.3) | 0.44 |
Cortical area, mm2 | 0.02 (−0.20 to 0.24) | 0.87 | −0.22 (−0.56 to 0.13) | 0.21 |
Tb area, mm2 | −0.46 (−1.25 to 0.31) | 0.25 | −0.58 (−2.68 to 1.52) | 0.58 |
Volumetric density | ||||
Total vBMD, mg/cm3 | 0.12 (−1.27 to 1.51) | 0.86 | −0.77 (−1.69 to 0.15) | 0.10 |
Cortical vBMD, mg/cm3 | 0.61 (−0.81 to 1.03) | 0.86 | 0.016 (−1.13 to 1.17) | 0.98 |
Tb vBMD, mg/cm3 | −0.59 (−1.33 to 0.15) | 0.11 | −0.65 (−1.21 to −0.08) | 0.03 |
Microarchitecture | ||||
Tb bone volume fraction | −0.0005 (−0.001 to 0.000) | 0.11 | −0.0005 (−0.010 to −0.0001) | 0.03 |
Tb thickness, mm | −0.0000 (−0.0003 to 0.0002) | 0.79 | −0.0000 (−0.0003 to 0.0024) | 0.96 |
Tb numbers, 1/mm | −0.007 (−0.013 to −0.001) | 0.02 | −0.006 (−0.011 to −0.001) | 0.02 |
Tb inhomogeneity | 0.002 (0.001 to 0.003) | 0.005 | 0.001 (0.000 to 0.002) | 0.04 |
Cortical thickness, mm | 0.001 (−0.004 to 0.006) | 0.59 | −0.019 (−0.007 to 0.003) | 0.43 |
Cortical porosity, % | −0.0001 (−0.0004 to 0.0003) | 0.56 | −0.0001 (−0.0006 to 0.0003) | 0.55 |
Statistical significance (p<0.05) is highlighted in bold.
*Adjusted for age, sex, height and body mass index.
HbA1c, glycated hemoglobin; HR-pQCT, high-resolution peripheral quantitative CT; Tb, trabecular bone; vBMD, volumetric bone mineral density.