Table 4

Latest year HbA1c adjusted* associations with HR-pQCT results

	Radius		Tibia
	Coef. (95% CI)	P value	Coef. (95% CI)	P value
Bone strength
Failure load, N	−3.7 (−15.6 to 8.2)	0.54	−26.7 (−52.7 to −0.7)	0.04
Geometry
Total bone area, mm²	−0.45 (−1.21 to 0.32)	0.2	−0.8 (−2.9 to 1.3)	0.44
Cortical area, mm²	0.02 (−0.20 to 0.24)	0.87	−0.22 (−0.56 to 0.13)	0.21
Tb area, mm²	−0.46 (−1.25 to 0.31)	0.25	−0.58 (−2.68 to 1.52)	0.58
Volumetric density
Total vBMD, mg/cm³	0.12 (−1.27 to 1.51)	0.86	−0.77 (−1.69 to 0.15)	0.10
Cortical vBMD, mg/cm³	0.61 (−0.81 to 1.03)	0.86	0.016 (−1.13 to 1.17)	0.98
Tb vBMD, mg/cm³	−0.59 (−1.33 to 0.15)	0.11	−0.65 (−1.21 to −0.08)	0.03
Microarchitecture
Tb bone volume fraction	−0.0005 (−0.001 to 0.000)	0.11	−0.0005 (−0.010 to −0.0001)	0.03
Tb thickness, mm	−0.0000 (−0.0003 to 0.0002)	0.79	−0.0000 (−0.0003 to 0.0024)	0.96
Tb numbers, 1/mm	−0.007 (−0.013 to −0.001)	0.02	−0.006 (−0.011 to −0.001)	0.02
Tb inhomogeneity	0.002 (0.001 to 0.003)	0.005	0.001 (0.000 to 0.002)	0.04
Cortical thickness, mm	0.001 (−0.004 to 0.006)	0.59	−0.019 (−0.007 to 0.003)	0.43
Cortical porosity, %	−0.0001 (−0.0004 to 0.0003)	0.56	−0.0001 (−0.0006 to 0.0003)	0.55

Statistical significance (p<0.05) is highlighted in bold.
*Adjusted for age, sex, height and body mass index.
HbA1c, glycated hemoglobin; HR-pQCT, high-resolution peripheral quantitative CT; Tb, trabecular bone; vBMD, volumetric bone mineral density.