Table 3

Factors involved in wound healing as reported in the included studies

Reference	Species	Reported factors that delayed wound healing	Treatment	Reported factors that improved wound healing
14	Rat	↓ Myofibroblast quantification ↓ Collagen type1 mRNA ↓ Wound contraction ↓ Neovascularization	None	NA
15	Mice	↓ Collagen content ↓ Granulation tissue thickness ↑ Apoptosis ↑ c-myc and β-catenin expression ↓ Capillary density	P66Shc Knockout	↑ Collagen content ↑ Granulation tissue thickness ↓ Apoptosis ↓ c-myc and β-catenin expression ↑ Capillary density
16	Rabbit	↓ Myofibroblast differentiation	Bone marrow aspirate & Platelet rich plasma	↑ Myofibroblast differentiation
17	Rats	↓ Myofibroblast differentiation ↓ Wound contraction	None	NA
18	Rats	↓ Wound contraction and re-epithelialization ↓ Collagen deposition	Hyperbaric oxygen therapy	↑ Blood flow and wound closure ↑ Wound contraction and re-epithelialization ↑ Collagen deposition
19	Mice	↓ Capillary density ↑ Leukocyte infiltration	Akkermansia muciniphila	↑ Capillary density ↓ Leukocyte infiltration
20	Mice	↑TNF-α ↓VEGF-A ↓Interleukin-8 ↓ b-FGF ↓ Cell migration ↓ Cell invasion	Sirt1 agonist SRT1720	↓ TNF-α ↑ VEGF-A ↑ Interleukin-8 ↑ b-FGF ↑ Cell migration ↑ Cell invasion

b-FGF, basic fibroblast growth factor; NA, not applicable; TNF, tumor necrosis factor; VEGF-A, vascular endothelial growth factor.