Clinical relevance assessment of the included studies
| Criteria | Study | ||||||
| 14 | 15 | 16 | 17 | 18 | 19 | 20 | |
| Species | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Was ischemia created in a limb as generally seen in patients? | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Was the ischemia created via ligation of an iliac, femoral or saphenous or popliteal artery? | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Was the blood flow assessed? | 1 | 1 | 0 | 1 | 1 | 0 | 0 |
| Was the wound located in the paw to mimic a foot ulcer seen in patients? | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
| Did the animals have diabetes? | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
| Did the animals have peripheral neuropathy? | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Were the animals aged an equivalent of over 50 years of human age? | 0 | 0* | 0* | 0 | 0* | 0 | 0 |
| Did the study report complete wound healing data? | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
| Score of 9=100% | 5 | 4 | 2 | 6 | 6 | 3 | 3 |
| Total score (%) | 55.5 | 44.4 | 22.2 | 66.6 | 66.6 | 33.3 | 33.3 |
1=Yes; 0=No.
*Not reported.