Table 2

Discrimination of faster eGFR decline with or without urinary SMTNL2 DNA methylation in patients with diabetes

ModelC-statisticsNRIEvent NRINon-event NRIIDI
Model 10.701 (0.554 to 0.816)
Model 1+SMTNL20.759 (0.620 to 0.859)0.542 (p=0.02)13.04%41.18%0.056 (p=0.03)
Model 20.788 (0.664 to 0.875)
Model 2+SMTNL20.825 (0.702 to 0.904)0.629 (p=0.009)21.74%41.18%0.084 (p=0.01)
  • Model 1, eGFR and urinary log Alb/Cr.

  • Model 2, age, sex, eGFR, log Alb/Cr, HbA1c, use of renin-angiotensin-aldosterone system inhibitors and systolic blood pressure; SMTNL2, DNA methylation levels of SMTNL2 in urine sediment.

  • C-statistics are represented as mean (95% CI). Category-free NRI and IDI are represented as values (two-sided P values). Components of NRI are presented as event and non-event NRI.

  • eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin A1c; IDI, integrated discrimination improvement; log Alb/Cr, log-transformed albumin-to-creatinine ratio; NRI, net reclassification improvement.