Table 3

Association between annual change in eGFR and variables in the validation cohort

VariableUnivariateMultivariateMultivariate without HbA1c and Alb/Cr
Coefficient (SE)P valueCoefficient (SE)P valueCoefficient (SE)P value
Age0.04 (0.04)0.32
SBP−0.001 (0.04)0.98
HbA1c−1.62 (0.56)0.01
eGFR0.05 (0.02)0.040.04 (0.02)0.110.05 (0.02)0.05
Alb/Cr−1.84 (0.53)0.002−1.62 (0.52)0.01
SMTNL20.13 (0.05)0.030.11 (0.05)0.04
  • Values mentioned here are regression coefficients (SE).

  • Alb/Cr, urinary log-transformed albumin-to-creatinine ratio; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin A1c; SBP, systolic blood pressure; SMTNL2, DNA methylation levels of SMTNL2 in urine sediment.