Association between annual change in eGFR and variables in the validation cohort
| Variable | Univariate | Multivariate | Multivariate without HbA1c and Alb/Cr | |||
| Coefficient (SE) | P value | Coefficient (SE) | P value | Coefficient (SE) | P value | |
| Age | 0.04 (0.04) | 0.32 | ||||
| SBP | −0.001 (0.04) | 0.98 | ||||
| HbA1c | −1.62 (0.56) | 0.01 | ||||
| eGFR | 0.05 (0.02) | 0.04 | 0.04 (0.02) | 0.11 | 0.05 (0.02) | 0.05 |
| Alb/Cr | −1.84 (0.53) | 0.002 | −1.62 (0.52) | 0.01 | ||
| SMTNL2 | 0.13 (0.05) | 0.03 | 0.11 (0.05) | 0.04 | ||
Values mentioned here are regression coefficients (SE).
Alb/Cr, urinary log-transformed albumin-to-creatinine ratio; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin A1c; SBP, systolic blood pressure; SMTNL2, DNA methylation levels of SMTNL2 in urine sediment.