Table 2

Retinal and CT and volume measurements and CVI of macular and subfoveal layers (N=167)

Group 1
(n=74)
Group 2
(n=75)
Group 3
(n=18)
Overall P value*Model 1
P value†
Model 2
P value‡
Total retina volume (mm3)8.53 (0.38)8.49 (0.38)8.40 (0.45)0.450.550.39
Subfoveal retina thickness (μm)277.54 (24.81)275.13 (24.86)285.94 (21.75)0.250.560.09
Total RNFL volume (mm3)0.93 (0.12)0.91 (0.11)0.90 (0.11)0.470.300.76
Subfoveal RNFL thickness (μm)16.71 (4.78)16.27 (5.96)17.94 (5.01)0.490.620.27
RGC volume (mm3)1.03 (0.08)1.10 (0.09)1.00 (0.09)0.190.090.92
Subfoveal RGC thickness (μm)20.24 (6.03)18.99 (6.02)20.89 (4.58)0.300.210.21
Inner plexiform layer volume (mm3)0.85 (0.07)0.83 (0.06)0.83 (0.05)0.160.080.91
Subfoveal inner plexiform thickness (μm)21.86 (4.71)20.97 (4.76)23.22 (4.01)0.160.260.07
INL volume (mm3)1.07 (0.07)1.01 (0.08)1.00 (0.03)0.060.460.70
Subfoveal INL thickness (μm)26.82 (5.04)27.41 (6.32)29.33 (5.19)0.250.530.24
OPL volume (mm3)0.76 (0.07)0.77 (0.07)0.75 (0.04)0.780.630.53
Subfoveal OPL thickness (μm)27.82 (6.92)28.56 (0.81)29.06 (3.80)0.700.520.77
ONL volume (mm3)1.67 (0.19)1.70 (0.14)1.65 (0.25)0.350.230.21
Subfoveal ONL thickness (μm)79.78 (12.81)78.80 (10.59)80.22 (12.73)0.840.610.62
Retinal pigment epithelial volume (mm3)0.45 (0.04)0.44 (0.04)0.45 (0.06)0.510.410.33
Subfoveal retinal pigment epithelium thickness (μm)18/08 (1.96)17.84 (2.01)18.44 (4.58)0.600.460.39
Photoreceptor layer volume (mm3)2.28 (0.07)2.45 (0.87)2.72 (1.34)0.060.090.29
Subfoveal photoreceptor layer thickness (μm)88.24 (4.18)92.39 (20.42)92.39 (32.13)0.070.090.32
Choroidal volume (mm3)8.61 (1.69)8.35 (1.40)7.38 (1.52)0.020.320.016
Subfoveal CT (μm)312.14 (68.61)307.16 (62.47)269.50 (64.67)0.0470.650.025
CVI across different groups
 Subfoveal Haller’s layer (SD)0.46 (0.07)0.45 (0.07)0.44 (0.0)0.330.210.71
 Subfoveal Sattler’s layer (SD)0.46 (0.11)0.45 (0.10)0.40 (0.15)0.130.660.08
 Macular Haller’s layer (SD)0.45 (0.05)0.44 (0.05)0.42 (0.06)0.020.0340.21
 Macular Sattler’s layer (SD)0.46 (0.08)0.44 (0.07)0.42 (0.12)0.170.170.36
  • Data are expressed as numbers (percentages) for categorical variables or means (SDs) for continuous variables.

  • Bold values are statistically significant.

  • *Based on χ2 or Wilcoxon test (categorical), or independent sample t-tests, comparing characteristics across all three groups.

  • †Based on χ2 or Wilcoxon test (categorical), or independent sample t-tests, comparing characteristics between groups 1 and 2.

  • ‡Based on χ2 or Wilcoxon test (categorical), or independent sample t-tests, comparing characteristics between groups 2 and 3.

  • CT, choroidal thickness; CVI, Choroidal Vascularity Index; INL, inner nuclear layer; ONL, outer nuclear layer; OPL, outer plexiform lay; RGC, retinal ganglion cell; RNFL, retinal nerve fiber layer.