Group 1 (n=74) | Group 2 (n=75) | Group 3 (n=18) | Overall P value* | Model 1 P value† | Model 2 P value‡ | |
Total retina volume (mm3) | 8.53 (0.38) | 8.49 (0.38) | 8.40 (0.45) | 0.45 | 0.55 | 0.39 |
Subfoveal retina thickness (μm) | 277.54 (24.81) | 275.13 (24.86) | 285.94 (21.75) | 0.25 | 0.56 | 0.09 |
Total RNFL volume (mm3) | 0.93 (0.12) | 0.91 (0.11) | 0.90 (0.11) | 0.47 | 0.30 | 0.76 |
Subfoveal RNFL thickness (μm) | 16.71 (4.78) | 16.27 (5.96) | 17.94 (5.01) | 0.49 | 0.62 | 0.27 |
RGC volume (mm3) | 1.03 (0.08) | 1.10 (0.09) | 1.00 (0.09) | 0.19 | 0.09 | 0.92 |
Subfoveal RGC thickness (μm) | 20.24 (6.03) | 18.99 (6.02) | 20.89 (4.58) | 0.30 | 0.21 | 0.21 |
Inner plexiform layer volume (mm3) | 0.85 (0.07) | 0.83 (0.06) | 0.83 (0.05) | 0.16 | 0.08 | 0.91 |
Subfoveal inner plexiform thickness (μm) | 21.86 (4.71) | 20.97 (4.76) | 23.22 (4.01) | 0.16 | 0.26 | 0.07 |
INL volume (mm3) | 1.07 (0.07) | 1.01 (0.08) | 1.00 (0.03) | 0.06 | 0.46 | 0.70 |
Subfoveal INL thickness (μm) | 26.82 (5.04) | 27.41 (6.32) | 29.33 (5.19) | 0.25 | 0.53 | 0.24 |
OPL volume (mm3) | 0.76 (0.07) | 0.77 (0.07) | 0.75 (0.04) | 0.78 | 0.63 | 0.53 |
Subfoveal OPL thickness (μm) | 27.82 (6.92) | 28.56 (0.81) | 29.06 (3.80) | 0.70 | 0.52 | 0.77 |
ONL volume (mm3) | 1.67 (0.19) | 1.70 (0.14) | 1.65 (0.25) | 0.35 | 0.23 | 0.21 |
Subfoveal ONL thickness (μm) | 79.78 (12.81) | 78.80 (10.59) | 80.22 (12.73) | 0.84 | 0.61 | 0.62 |
Retinal pigment epithelial volume (mm3) | 0.45 (0.04) | 0.44 (0.04) | 0.45 (0.06) | 0.51 | 0.41 | 0.33 |
Subfoveal retinal pigment epithelium thickness (μm) | 18/08 (1.96) | 17.84 (2.01) | 18.44 (4.58) | 0.60 | 0.46 | 0.39 |
Photoreceptor layer volume (mm3) | 2.28 (0.07) | 2.45 (0.87) | 2.72 (1.34) | 0.06 | 0.09 | 0.29 |
Subfoveal photoreceptor layer thickness (μm) | 88.24 (4.18) | 92.39 (20.42) | 92.39 (32.13) | 0.07 | 0.09 | 0.32 |
Choroidal volume (mm3) | 8.61 (1.69) | 8.35 (1.40) | 7.38 (1.52) | 0.02 | 0.32 | 0.016 |
Subfoveal CT (μm) | 312.14 (68.61) | 307.16 (62.47) | 269.50 (64.67) | 0.047 | 0.65 | 0.025 |
CVI across different groups | ||||||
Subfoveal Haller’s layer (SD) | 0.46 (0.07) | 0.45 (0.07) | 0.44 (0.0) | 0.33 | 0.21 | 0.71 |
Subfoveal Sattler’s layer (SD) | 0.46 (0.11) | 0.45 (0.10) | 0.40 (0.15) | 0.13 | 0.66 | 0.08 |
Macular Haller’s layer (SD) | 0.45 (0.05) | 0.44 (0.05) | 0.42 (0.06) | 0.02 | 0.034 | 0.21 |
Macular Sattler’s layer (SD) | 0.46 (0.08) | 0.44 (0.07) | 0.42 (0.12) | 0.17 | 0.17 | 0.36 |
Data are expressed as numbers (percentages) for categorical variables or means (SDs) for continuous variables.
Bold values are statistically significant.
*Based on χ2 or Wilcoxon test (categorical), or independent sample t-tests, comparing characteristics across all three groups.
†Based on χ2 or Wilcoxon test (categorical), or independent sample t-tests, comparing characteristics between groups 1 and 2.
‡Based on χ2 or Wilcoxon test (categorical), or independent sample t-tests, comparing characteristics between groups 2 and 3.
CT, choroidal thickness; CVI, Choroidal Vascularity Index; INL, inner nuclear layer; ONL, outer nuclear layer; OPL, outer plexiform lay; RGC, retinal ganglion cell; RNFL, retinal nerve fiber layer.