Only weight reduction model
| Biological factors related to hyperglycemia | Threshold | Relevance |
| Fasting glucose | <118–133 mg/dL | 0.07 |
| A1c reduction speed | >−0.10 point HbA1c/year | 0.81 |
| Distance from target 7% | <0.7–0.9 point HbA1c | 0.12 |
| Biological factors related to insulin resistance | Threshold | Relevance |
| BP systolic | <115–125 mm Hg | 0.03 |
| Total cholesterol | <189 mg/dL | 0.04 |
| Triglycerides | <125 mg/dL | 0.02 |
| HDL | >47 | 0.02 |
| Hystory and care | Threshold or condition | Relevance |
| Years of observation | >10 | 0.16 |
| Interval between visits (yeras) | <0.4–0.6 | 0.28 |
| BMI | >26–28 | 0.12 |
| Diabetes therapy | Condition | Relevance |
| Agents | Absent | 0.09 |
| SGLT2i, GLP1-RA, DPP-4i, INS+SGLT2 i, INS+GLP1 RA, INS+DPP-4i | Present | 0.09 |
The model identifies the following factors as relevant for achieving the target: AUC 0.55, accuracy 0.62, sensitivity 0.65, specificity 0.48, precision 0.82, NPV 0.29.
AUC, area under the curve; BMI, body mass index; BP, blood pressure; DPP-4i, dipeptidyl peptidase 4 inhibitor; GLP-1RA, glucagon-like peptide-1 receptor agonists; HDL, high density lipoprotein; INS, insulin; NPV, negative predictive value; SGLT2i, sodium-glucose cotransporter-2 inhibitors.