Table 4

Univariate analysis for correlations between weight loss-induced changes in serum and urine mtND-1 and mtCOX-3 copy number and the changes in other variables in patients with obesity with T2DM

Variables (Δ)Δ serum mtND-1Δ serum mtCOX-3Δ urine mtND-1Δ urine mtCOX-3
rP valuerP valuerP valuerP value
Weight, kg0.2310.448−0.0480.875−0.2370.415−0.1050.721
BMI, kg/m2−0.1080.7260.2850.3450.3500.2200.1670.569
Systolic BP, mm Hg0.5450.1040.5610.0920.2020.5510.1420.677
Diastolic BP, mm Hg0.761*0.0110.744*0.0140.1600.6380.2940.380
eGFR CKD-EPI by cysC, mL/min/1.73 m2−0.4010.174−0.3310.2700.539*0.0470.548*0.043
AST−0.1100.721−0.0440.886−0.5270.053−0.5040.066
ALT−0.0700.821−0.2150.481−0.4870.078−0.3440.229
Triglyceride, mg/dL0.2460.4190.3990.1770.2490.3910.1890.517
LDL cholesterol, mg/dL−0.2120.488−0.2280.454−0.0590.841−0.1790.540
HDL cholesterol, mg/dL−0.0080.978−0.2230.464−0.0140.9610.0240.936
Glucose, mg/dL0.4540.1190.3830.1960.0740.8010.0670.821
HbA1c0.708**0.0070.555*0.0490.0890.7620.1380.639
Urinary protein, mg/day−0.1220.691−0.2810.352−0.0250.931−0.0030.993
Urinary albumin, mg/day−0.1700.579−0.2500.410−0.0090.9760.0000.999
  • Values are Pearson’s correlation coefficients and associated p values. Values in bold indicate statistically significant correlation at a value of p<0.05.

  • *P<0.05, **p<0.005.

  • ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; BP, blood pressure; CKD-EPI, CKD Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; LDL, low-density lipoprotein; mtCOX-3, mitochondrial cytochrome-c oxidase 3; mtND-1, mitochondrial nicotinamide adenine dinucleotide dehydrogenase subunit-1; T2DM, type 2 diabetes mellitus.