Table 3

Univariate analysis for correlations between weight loss-induced changes in serum and urine mtND-1 and mtCOX-3 copy number and the changes in other variables in patients with obesity

Variables (Δ)Δ serum mtND-1Δ serum mtCOX-3Δ urine mtND-1Δ urine mtCOX-3
rP valuerP valuerP valuerP value
Weight, kg−0.0460.7690.0240.877−0.1760.254−0.1090.480
BMI, kg/m20.1190.4460.0700.6550.2100.1720.1500.332
Systolic BP, mm Hg0.1710.3180.0640.7120.2140.2030.1430.399
Diastolic BP, mm Hg0.362*0.0300.2720.1080.1090.5220.1080.524
eGFR CKD-EPI by cysC, mL/min/1.73 m20.360*0.0470.357*0.0490.2250.2160.2340.198
AST0.1280.4450.0610.7160.0270.8710.0420.801
ALT0.1210.468−0.0320.8480.0230.8890.0730.659
Triglyceride, mg/dL0.0800.6420.1360.428−0.2700.106−0.2900.082
LDL cholesterol, mg/dL−0.0060.969−0.0800.628−0.0670.680−0.0710.661
HDL cholesterol, mg/dL−0.0160.927−0.0420.816−0.0040.983−0.0390.826
Glucose, mg/dL0.0910.5820.0670.6860.0520.750−0.0150.929
HbA1c−0.0030.985−0.0390.8060.0480.7580.0350.826
Urinary protein, mg/day−0.2500.175−0.3030.097−0.0400.829−0.0760.679
Urinary albumin, mg/day−0.2220.230−0.2330.208−0.0780.679−0.1140.540
  • Values are Pearson’s correlation coefficients and associated p values. Values in bold indicate statistically significant correlation at a value of p<0.05.

  • *P<0.05, **p<0.005.

  • ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; BP, blood pressure; CKD-EPI, CKD Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; LDL, low-density lipoprotein; mtCOX-3, mitochondrial cytochrome-c oxidase 3; mtND-1, mitochondrial nicotinamide adenine dinucleotide dehydrogenase subunit-1.