Table 3

Cross-sectional and longitudinal association between baseline vitamin B12 and baseline FBG, exit FBG and change in FBG (ΔFBG)

Baseline vitamin B12Cross-sectional*Longitudinal†
Mean (SD)Baseline FBGMean (SD)Exit FBGMean (SD)ΔFBG
Non-adjustedAdjustedNon-adjustedAdjustedNon-adjustedAdjusted
β (95% CI), p valueβ (95% CI), p valueβ (95% CI), p valueβ (95% CI), p valueβ (95% CI), p valueβ (95% CI), p value
Continuous (per IQR)5.8 (1.7)0.16 (0.13 to 0.19), <0.0010.14 (0.11 to 0.17), <0.0016.3 (2.0)0.13 (0.09 to 0.17), <0.001−0.01 (−0.04 to 0.02), 0.6020.5 (1.6)−0.02 (−0.05 to 0.01), 0.163−0.01 (−0.04 to 0.02), 0.602
Quartiles
 Q15.6 (1.3)006.1 (1.7)000.5 (1.5)00
 Q25.8 (1.5)0.11 (0.04 to 0.18), 0.0020.03 (−0.04 to 0.09), 0.3816.2 (2.0)0.07 (−0.01 to 0.16), 0.094−0.01 (−0.08 to 0.05), 0.7360.5 (1.7)−0.04 (−0.11 to 0.03), 0.241−0.01 (−0.08 to 0.05), 0.696
 Q35.9 (1.7)0.23 (0.16 to 0.31), <0.0010.13 (0.06 to 0.19), <0.0016.3 (2.1)0.19 (0.10 to 0.28), <0.0010.00 (−0.06 to 0.07), 0.9350.5 (1.7)−0.05 (−0.12 to 0.02), 0.144−0.00 (−0.07 to 0.06), 0.979
 Q45.9 (2.1)0.31 (0.24 to 0.38), <0.0010.26 (0.20 to 0.33), <0.0016.4 (2.2)0.23 (0.14 to 0.32), <0.001−0.03 (−0.10 to 0.03), 0.3250.4 (1.7)−0.05 (−0.12 to 0.02), 0.168−0.03 (−0.10 to 0.03), 0.316
P for trend<0.001<0.001<0.0010.4620.1620.405

  • *Adjusted for age, sex, MTHFR gene C677T polymorphisms, SBP and DBP at baseline, body mass index, study center, serum concentrations of folate, homocysteine, total cholesterol, triglycerides, and high-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, smoking status, alcohol consumption status, meat consumption, lipid-lowering drugs and antihypertensive drugs.

  • †Adjusted for age, sex, MTHFR gene C677T polymorphisms, SBP and DBP at baseline, mean SBP and DBP during the treatment period, body mass index, study center, baseline serum concentrations of folate, homocysteine, FBG, total cholesterol, triglycerides, and high-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, treatment group, smoking status, alcohol consumption status, meat consumption, lipid-lowering drugs and antihypertensive drugs.

  • DBP, diastolic blood pressure; FBG, fasting blood glucose; MTHFR, methylenetetrahydrofolate reductase; SBP, systolic blood pressure.