Table 4

Mediation analysis with adverse birth outcomes as potential mediators between maternal diabetes and risk of feeding and eating disorders in offspring

VariablesOR (95% CI)*
Low birth weight
 Natural direct effect1.55 (1.25 to 1.83)
 Natural indirect effect1.03 (1.02 to 1.04)
 Total effect1.60 (1.29 to 1.88)
 Proportion (%)†6.29
Preterm birth
 Natural direct effect1.49 (1.20 to 1.75)
 Natural indirect effect1.09 (1.07 to 1.11)
 Total effect1.62 (1.30 to 1.91)
 Proportion (%)17.86
Low Apgar score
 Natural direct effect1.61 (1.30 to 1.90)
 Natural indirect effect1.00 (1.00 to 1.01)
 Total effect1.62 (1.31 to 1.91)
 Proportion (%)0.99
  • *Adjusted for sex, birth year, parity, parental age, maternal smoking during pregnancy, maternal education level, maternal country of origin, maternal cohabitation and maternal psychiatric disorders.

  • †Proportion mediated was calculated as log (natural indirect relationship)/log (total relationship).