Interaction between rs10811661 and BMI level on T2D risk
| BMI* | Genotype | Case N (%) | Control N (%) | OR (95% CI)† | P value† |
| <18.50 | CC | 9 (0.31%) | 36 (1.10%) | 0.80 (0.38 to 1.70) | 0.565 |
| 18.50–24.99 | CC | 171 (5.93%) | 575 (17.65%) | 1 | – |
| 25.00–27.99 | CC | 236 (8.19%) | 138 (4.24%) | 5.67 (4.31 to 7.46) | <0.001 |
| ≥28 | CC | 102 (3.54%) | 19 (0.58%) | 18.43 (10.95 to 31.02) | <0.001 |
| <18.50 | TC | 35 (1.21%) | 85 (2.61%) | 1.41 (0.91 to 2.18) | 0.12 |
| 18.50–24.99 | TC | 519 (18.01%) | 1238 (38.00%) | 1.42 (1.16 to 1.73) | 0.001 |
| 25.00–27.99 | TC | 628 (21.79%) | 263 (8.07%) | 8.13 (6.49 to 10.19) | <0.001 |
| ≥28 | TC | 294 (10.20%) | 47 (1.44%) | 22.01 (15.37 to 31.51) | <0.001 |
| <18.50 | TT | 23 (0.80%) | 62 (1.90%) | 1.21 (0.72 to 2.02) | 0.467 |
| 18.50–24.99 | TT | 364 (12.63%) | 612 (18.78%) | 1.98 (1.60 to 2.46) | <0.001 |
| 25.00–27.99 | TT | 352 (12.21%) | 153 (4.70%) | 7.51 (5.80 to 9.71) | <0.001 |
| ≥28 | TT | 149 (5.18%) | 30 (0.93%) | 17.58 (11.38 to 27.16) | <0.001 |
| P for multiplicative interaction | 0.003 | ||||
*BMI was divided into four groups based on Chinese criterion: underweight: <18.50; normal: 18.50–23.99; overweight: 24.00–27.99; obesity: ≥28.00.
†OR and p value were calculated by multiplicative interaction logistic regression with adjustment of rs10811661, BMI, age, sex, smoking and alcohol consumption.
BMI, body mass index; T2D, type 2 diabetes.