Table 2

Interaction between selected SNPs and BMI levels on T2D risk

Gene	SNP	Allele*	MAF	Wuxi study		Changzhou-Nantong study		Combined
Gene	SNP	Allele*	MAF	OR†	P value†	OR†	P value†	OR (95% CI)†	P value†	FDR-P
CDKN2A/CDKN2B	rs10811661	T/C	0.487	1.22	0.033	1.21	0.035	1.22 (1.07 to 1.39)	0.003	0.021
CENTD2	rs1552224	A/C	0.087	1.08	0.626	1.52	0.018	1.23 (0.97 to 1.55)	0.084	0.196
KCNQ1	rs2237892	C/T	0.341	1.02	0.822	1.12	0.250	1.06 (0.92 to 1.21)	0.430	0.502
KCNQ1	rs2237895	A/C	0.312	0.94	0.555	0.82	0.035	0.88 (0.77 to 1.01)	0.061	0.196
SLC30A8	rs13266634	C/T	0.445	1.10	0.312	1.02	0.855	1.03 (0.91 to 1.17)	0.615	0.615
TP53INP1	rs896854	C/T	0.347	1.16	0.120	1.20	0.068	1.18 (0.97 to 1.25)	0.153	0.262
VEGFA	rs9472138	C/T	0.110	0.84	0.203	0.94	0.679	0.88 (0.73 to 1.06)	0.187	0.262

*Major/Minor allele.
†OR and p value were calculated by multiplicative interaction logistic regression with adjustment of SNP, BMI, age, sex, smoking and alcohol consumption.
BMI, body mass index; FDR-P, false discovery rate P value; MAF, minor allele frequency; SNP, single nucleotide polymorphism; T2D, type 2 diabetes.