Table 1

Participant characteristics11

CONNAFL−NAFL+NASH
Number (females)7 (5)7 (6)7 (4)7 (6)
Age (years)40±1343±746±1242±8
BMI (kg/m2)25.2±3.3†§**49.5±8.356.1±7.051.4±7.1
Waist circumference (cm)82.8±13.0*§¶125.7±19.8††144.5±16.2129.2±17.0
Fasting blood glucose (mg/dL)75±7 ‡93±1398±2885±6
Fasting plasma insulin (mIU/L)6.1 (5.1, 10.8)*‡22.6 (12.3, 25.9)33.6 (32.4, 34.3)22.8 (16.3, 31.7)
HbA1c (%)5.3±0.3*‡5.6±0.56.0±0.95.5±0.2
HbA1c (mmol/mol)34±3*‡38±642±1037±2
Peripheral insulin sensitivity (mg/kg/min)7.4±2.2*‡3.1±1.71.8±0.32.8±0.6
HCL (%)1 (0, 5)‡**2 (0, 5)‡‡§§40 (10, 40)¶¶45 (40, 65)
  • Data are presented as mean±SD or median (q1, q3).

  • *p≤0.01, CON vs NAFL−.

  • †p<0.001, CON vs NAFL−.

  • ‡p≤0.01, CON vs NAFL+.

  • §p<0.001, CON vs NAFL+.

  • ¶p≤0.01, CON vs NASH.

  • **p<0.001, CON vs NASH.

  • ††p≤0.05, NAFL− vs NAFL+.

  • ‡‡p≤0.01, NAFL− vs NAFL+.

  • §§p<0.001, NAFL− vs NASH.

  • ¶¶p≤0.05, NAFL+ vs NASH.

  • BMI, body mass index; CON, control; HCL, hepatocellular lipids; NAFL, non-alcoholic fatty liver; NASH, non-alcoholic steatohepatitis.