Mendelian randomization (MR) estimates between accelerometer-based sedentary behavior (MET ≤1.5) and type 2 diabetes and glycemic traits
| Method | No. of SNPs | OR/beta | 95% CI | P value | Outcome |
| Inverse variance weighted (multiplicative random effects) | 5 | 0.86 | (0.69 to 1.08) | 0.190 | Type 2 diabetes |
| Weighted median | 5 | 0.80 | (0.60 to 1.08) | 0.141 | Type 2 diabetes |
| MR-PRESSO: raw | 6 | 0.86 | (0.69 to 1.08) | 0.260 | Type 2 diabetes |
| MRMix | 6 | 1.00 | (0.58 to 1.73) | 1.000 | Type 2 diabetes |
| Inverse variance weighted (multiplicative random effects) | 4 | 0.010 | (−0.078 to 0.099) | 0.818 | HbA1c |
| Weighted median | 4 | 0.030 | (−0.069 to 0.129) | 0.553 | HbA1c |
| MR-PRESSO: raw | 5 | 0.010 | (−0.078 to 0.099) | 0.833 | HbA1c |
| MRMix | 5 | 0.025 | (−0.130 to 0.180) | 0.751 | HbA1c |
| Inverse variance weighted (multiplicative random effects) | 3 | 0.014 | (−0.142 to 0.171) | 0.856 | Fasting glucose |
| Weighted median | 3 | 0.045 | (−0.144 to 0.234) | 0.643 | Fasting glucose |
| MRMix | 4 | 0.025 | (−0.185 to 0.235) | 0.816 | Fasting glucose |
| Inverse variance weighted (multiplicative random effects) | 3 | 0.001 | (−0.264 to 0.267) | 0.991 | HOMA-B |
| Weighted median | 3 | 0.126 | (−0.068 to 0.319) | 0.203 | HOMA-B |
| MRMix | 4 | 0.230 | (−0.122 to 0.582) | 0.200 | HOMA-B |
| Inverse variance weighted (multiplicative random effects) | 3 | 0.023 | (−0.363 to 0.409) | 0.907 | HOMA-IR |
| Weighted median | 3 | 0.113 | (−0.154 to 0.38) | 0.407 | HOMA-IR |
| MRMix | 4 | 0.320 | (−0.078 to 0.718) | 0.115 | HOMA-IR |
HbA1c, hemoglobin A1c; HOMA-B, homeostasis model assessment of beta-cell function; HOMA-IR, homeostasis model assessment of insulin resistance ; MET, metabolic equivalent task; MR-PRESSO, MR-Pleiotropy RESidual Sum and Outlier; SNPs, single nucleotide polymorphisms.