Table 3

Mendelian randomization (MR) estimates between accelerometer-based sedentary behavior (MET ≤1.5) and type 2 diabetes and glycemic traits

MethodNo. of SNPsOR/beta95% CIP valueOutcome
Inverse variance weighted (multiplicative random effects)50.86(0.69 to 1.08)0.190Type 2 diabetes
Weighted median50.80(0.60 to 1.08)0.141Type 2 diabetes
MR-PRESSO: raw60.86(0.69 to 1.08)0.260Type 2 diabetes
MRMix61.00(0.58 to 1.73)1.000Type 2 diabetes
Inverse variance weighted (multiplicative random effects)40.010(−0.078 to 0.099)0.818HbA1c
Weighted median40.030(−0.069 to 0.129)0.553HbA1c
MR-PRESSO: raw50.010(−0.078 to 0.099)0.833HbA1c
MRMix50.025(−0.130 to 0.180)0.751HbA1c
Inverse variance weighted (multiplicative random effects)30.014(−0.142 to 0.171)0.856Fasting glucose
Weighted median30.045(−0.144 to 0.234)0.643Fasting glucose
MRMix40.025(−0.185 to 0.235)0.816Fasting glucose
Inverse variance weighted (multiplicative random effects)30.001(−0.264 to 0.267)0.991HOMA-B
Weighted median30.126(−0.068 to 0.319)0.203HOMA-B
MRMix40.230(−0.122 to 0.582)0.200HOMA-B
Inverse variance weighted (multiplicative random effects)30.023(−0.363 to 0.409)0.907HOMA-IR
Weighted median30.113(−0.154 to 0.38)0.407HOMA-IR
MRMix40.320(−0.078 to 0.718)0.115HOMA-IR
  • HbA1c, hemoglobin A1c; HOMA-B, homeostasis model assessment of beta-cell function; HOMA-IR, homeostasis model assessment of insulin resistance ; MET, metabolic equivalent task; MR-PRESSO, MR-Pleiotropy RESidual Sum and Outlier; SNPs, single nucleotide polymorphisms.