Correlation of SHBG changes with changes in hormone and glucose measures, overall and by treatment arm
| Change in FSH | Change in estradiol | Change in testosterone | Change in fasting glucose | Change in HbA1c | Change in 2-hour glucose | Change in HOMA-IR | Change in 1/fasting insulin | |
| Change in SHBG (overall) – correlation coefficient, p (n) | −0.19 p<0.001 (990) | 0.08 p<0.001 (1924) | 0.12 p<0.001 (1996) | −0.20 p<0.001 (2138) | −0.12 p<0.001 (2122) | −0.11 p<0.001 (2137) | −0.13 p<0.001 (2097) | 0.15 p<0.001 (2097) |
| Change in SHBG (placebo) – correlation coefficient, p (n) | −0.30 p<0.001 (351) | 0.12 p=0.003 (649) | 0.08 p=0.052 (674) | −0.19 p<0.001 (725) | −0.12 p=0.002 (716) | −0.06 p=0.097 (724) | −0.10 p=0.006 (708) | 0.10 p=0.010 (708) |
| Change in SHBG (metformin) – correlation coefficient, p (n) | −0.18 p=0.002 (310) | 0.02 p=0.533 (636) | 0.16 p<0.001 (656) | −0.11 p=0.003 (698) | −0.05 p=0.159 (696) | −0.03 p=0.356 (698) | −0.06 p=0.129 (684) | 0.09 p=0.024 (684) |
| Change in SHBG (intensive lifestyle intervention) – correlation coefficient, p (n) | −0.12 p=0.027 (329) | 0.10 p=0.016 (639) | 0.07 p=0.063 (666) | −0.24 p<0.001 (715) | −0.07 p=0.057 (710) | −0.13 p<0.001 (715) | −0.16 p<0.001 (705) | 0.18 p<0.001 (705) |
FSH, Follicle-Stimulating Hormone; HbA1c, hemoglobin A1c; HOMA-IR, homeostatic model assessment of insulin resistance; SHBG, sex hormone binding globulin.