Table 3

Diagnostic performance of quantitative sensory testing, nerve conduction and CCM in the diagnosis of diabetic peripheral neuropathy

Neuropathy measureAUCP valueSensitivity (%)Specificity (%)Youden’s cut-off point
VPT0.79<0.0001559017.37
WPT0.67<0.001507644.2
CPT0.64<0.002804727.3
SNCV0.70<0.01765445.9
CNFD0.71<0.0001588323.95
CNBD0.70<0.0001696558.54
CNFL0.68<0.0001646721.6
IWL0.72<0.0001706524.4
ANFL0.72<0.0001716623.4
  • ANFL, average nerve fiber length; AUC, area under the curve; CCM, corneal confocal microscopy; CNBD, corneal nerve branch density; CNFD, corneal nerve fiber density; CNFL, corneal nerve fiber length; CPT, cold perception threshold; IWL, inferior whorl length; SNCV, sural nerve conduction velocity; VPT, vibration perception threshold; WPT, warm perception threshold.