Prevalence and incidence of microvascular and macrovascular complications (N=135 199)
| (A) Microvascular complications and all-cause mortality | Chronic kidney disease | End-stage kidney disease | Proliferative diabetic retinopathy | Peripheral neuropathy | Lower extremity amputation | All-cause mortality | |
| Prevalent cases, N | 16 659 | 259 | 444 | 5115 | 155 | – | |
| Prevalence (%) (95% CI) | 12.3 (12.2 to 12.5) | 0.5 (0.5 to 0.6) | 0.3 (0.3 to 0.4) | 3.8 (3.7 to 3.9) | 0.1 (0.1 to 0.1) | – | |
| Patients at risk,* N | 118 540 | 134 940 | 134 755 | 130 084 | 135 044 | 135 199 | |
| Incident cases, N | 14 609 | 870 | 1353 | 19 957 | 554 | 16 401 | |
| Total person-years | 688 542 | 860 683 | 859 390 | 741 744 | 865 641 | 866 591 | |
| Incidence rate per 1000 person-years (95% CI) | 21.2 (20.9 to 21.6) | 1.0 (1.0 to 1.1) | 1.6 (1.5 to 1.7) | 26.9 (26.5 to 27.3) | 0.6 (0.6 to 0.7) | 18.9 (18.6 to 19.2) | |
| Median time to incidence | 3.2 | 5.0 | 3.8 | 3.3 | 5.2 | 4.5 | |
| Median time to follow-up | 5.3 | 5.9 | 5.9 | 5.2 | 6.0 | 6.0 | |
| Cumulative incidence (%) (95% CI) | |||||||
| Time (years) | |||||||
| 2 | 4.6 (4.5 to 4.7) | 0.2 (0.1 to 0.2) | 0.3 (0.3 to 0.4) | 5.6 (5.4 to 5.7) | 0.1 (0.1 to 0.1) | 3.3 (3.2 to 3.4) | |
| 5 | 10.1 (9.9 to 10.3) | 0.4 (0.4 to 0.4) | 0.73 (0.7 to 0.8) | 12.6 (12.4 to 12.8) | 0.2 (0.2 to 0.3) | 7.9 (7.7 to 8.0) | |
| 10 | 19.0 (18.7 to 19.4) | 1.1 (1.0 to 1.1) | 1.5 (1.5 to 1.6) | 23.4 (23.0 to 23.7) | 0.7 (0.6 to 0.8) | 17.7 (17.4 to 18.0) | |
| 13 | 24.0 (23.5 to 24.5) | 1.7 (1.5 to 1.8) | 2.2 (2.0 to 2.4) | 29.9 (29.4 to 30.4) | 1.0 (0.9 to 1.1) | 24.7 (24.2 to 25.1) | |
| 15 | 25.4 (24.9 to 26.0) | 2.0 (1.8 to 2.2) | 2.9 (2.3 to 3.6) | 33.4 (32.6 to 34.1) | 1.3 (1.0 to 1.6) | 30.0 (29.1 to 30.8) | |
| (B) Macrovascular complications | Myocardial infarction | Unstable angina | Stroke | Composite cardiovascular disease | Heart failure | Stable angina | Peripheral vascular disease |
| Prevalent cases, N | 1713 | 1504 | 1635 | 4388 | 4717 | 6150 | 2958 |
| Prevalence, % (95% CI) | 1.3 (1.2 to 1.3) | 1.1 (1.1 to 1.2) | 1.2 (1.2 to 1.3) | 3.3 (3.2 to 3.3) | 3.5 (3.4 to 3.6) | 4.6 (4.4 to 4.7) | 2.2 (2.1 to 2.3) |
| Patients at-risk,* N | 133 486 | 133 695 | 133 564 | 130 811 | 130 482 | 129 049 | 132 241 |
| Incident cases, N | 3519 | 2597 | 5578 | 9645 | 5846 | 5714 | 3967 |
| Total person-years | 846 149 | 846 776 | 843 872 | 809 482 | 823 805 | 801 065 | 830 215 |
| Incidence rate per 1000 person-years (95% CI) | 4.2 (4.0 to 4.3) | 3.1 (3.0 to 3.2) | 6.6 (6.4 to 6.8) | 11.9 (11.7 to 12.2) | 7.1 (6.9 to 7.3) | 7.1 (7.0 to 7.3) | 4.8 (4.6 to 4.9) |
| Median time to incidence | 4.0 | 3.3 | 4.4 | 3.9 | 4.3 | 3.0 | 3.0 |
| Median time to follow-up | 5.9 | 5.9 | 5.9 | 5.7 | 5.9 | 5.7 | 5.8 |
| Cumulative Incidence (%) (95% CI) | |||||||
| Time (years) | |||||||
| 2 | 0.8 (0.8 to 0.9) | 0.7 (0.7 to 0.8) | 1.1 (1.1 to 1.2) | 2.4 (2.3 to 2.5) | 1.3 (1.3 to 1.4) | 1.9 (1.8 to 1.9) | 1.2 (1.1 to 1.3) |
| 5 | 1.9 (1.8 to 2.0) | 1.6 (1.5 to 1.7) | 2.9 (2.8 to 3.0) | 5.4 (5.3 to 5.6) | 3.1 (3.0 to 3.2) | 3.6 (3.5 to 3.7) | 2.6 (2.5 to 2.7) |
| 10 | 4.0 (3.9 to 4.2) | 2.9 (2.8 to 3.0) | 6.5 (6.3 to 6.7) | 11.2 (11.0 to 11.5) | 7.0 (6.8 to 7.2) | 6.4 (6.2 to 6.6) | 4.6 (4.4 to 4.8) |
| 13 | 5.8 (5.6 to 6.1) | 3.8 (3.7 to 4.0) | 9.4 (9.0 to 9.7) | 15.5 (15.1 to 15.9) | 9.9 (9.5 to 10.2) | 8.6 (8.3 to 8.9) | 5.2 (5.0 to 5.4) |
| 15 | 7.6 (6.9 to 8.3) | 4.3 (4.0 to 4.6) | 11.2 (10.7 to 11.8) | 18.6 (17.8 to 19.5) | 11.5 (11.0 to 12.0) | 10.6 (9.8 to 11.4) | 5.4 (5.2 to 5.7) |
*Patients after excluding each prevalent complication.