Table 4

Association between baseline seasonal-standardized serum 25(OH)D level and the 11-year risk of T2DM, stratified by PRS for T2DM (N=3467*)

Seasonal-standardized serum
25(OH)D level (nmol/L)
Crude OR
(95% CI)
Adjusted OR
(95% CI)†
PRS low score (bottom 2/3)2312311.3
 <501297191.51.24 (0.60 to 2.57)1.00 (0.44 to 2.31)
 ≥501015121.21.00 (reference)1.00 (reference)
PRS high score (top 1/3)1155534.6
 <50691415.92.38 (1.23 to 4.57)1.78 (0.86 to 3.73)
 ≥50464122.61.00 (reference)1.00 (reference)
  • *107 participants were excluded due to missing genetic information.

  • †Adjusted for age, sex, education, economic difficulties, body mass index, smoking status, alcohol consumption, physical activity, sitting time per day, family history of diabetes and chronic diseases.

  • 25(OH)D, 25-hydroxyvitamin D; PRS, Polygenic Risk Score; T2DM, type 2 diabetes mellitus.