Table 2

Number events, event rates and incidence rate ratios by diabetes status and CAD status

EventsEvents per 100 person years (95% CI)10-year cumulative incidence* (95% CI)Unadjusted HR
(95% CI)
Adjusted HR†
(95% CI)
Peripheral artery disease
−DM −CAD11700.40 (0.38 to 0.43)3.53% (3.32 to 4.74)11
+DM −CAD2930.81 (0.73 to 0.91)6.89% (6.11 to 7.73)1.98 (1.74 to 2.25)1.73 (1.51 to 1.97)
−DM +CAD37591.02 (0.99 to 1.05)7.90% (7.65 to 8.16)2.48 (2.32 to 2.65)2.20 (2.04 to 2.37)
+DM +CAD13542.10 (1.99 to 2.22)14.56% (13.80 to 15.34)5.00 (4.63 to 5.41)3.90 (3.55 to 4.28)
Lower limb revascularization
−DM −CAD2890.10 (0.09 to 0.11)0.89% (0.79 to 1.00)11
+DM −CAD630.17 (0.13 to 0.22)1.56% (1.19 to 2.02)1.73 (1.31 to 2.27)1.55 (1.16 to 2.05)
−DM +CAD10900.29 (0.27 to 0.30)2.39% (2.24 to 2.54)2.89 (2.54 to 3.29)2.51 (2.17 to 2.91)
+DM +CAD3990.59 (0.53 to 0.65)4.48% (4.04 to 4.96)5.88 (5.05 to 6.84)4.61 (3.85 to 5.52)
Lower limb amputation
−DM −CAD1040.04 (0.03 to 0.04)0.34% (0.28 to 0.41)11
+DM −CAD1000.27 (0.22 to 0.33)2.42% (1.96 to 3.95)7.77 (5.91 to 10.23)5.51 (4.09 to 7.43)
−DM +CAD2480.06 (0.06 to 0.07)0.59% (0.52 to 0.67)1.84 (1.46 to 2.31)2.02 (1.57 to 2.60)
+DM +CAD3300.48 (0.43 to 0.54)3.81% (3.40 to 4.25)13.86 (11.12 to 17.28)9.49 (7.27 to 12.39)
Hip/femur amputation
−DM −CAD450.02 (0.01 to 0.02)11
+DM −CAD240.06 (0.04 to 0.10)4.30 (2.62 to 7.06)3.31 (1.95 to 5.61)
−DM +CAD1480.04 (0.03 to 0.05)2.54 (1.82 to 3.55)2.62 (1.81 to 2.79)
+DM +CAD1080.16 (0.13 to 0.19)10.46 (7.39 to 14.82)7.41 (4.87 to 11.28)
Knee/lower leg amputation
−DM −CAD360.01 (0.01 to 0.02)11
+DM −CAD370.10 (0.07 to 0.14)8.26 (5.22 to 13.07)5.19 (3.13 to 8.62)
−DM +CAD740.02 (0.02 to 0.02)1.58 (1.06 to 2.36)1.76 (1.14 to 2.74)
+DM +CAD1230.18 (0.15 to 0.21)14.76 (10.18 to 21.41)9.00 (5.69 to 14.23)
Ankle/foot/toe amputation
−DM −CAD380.01 (0.01 to 0.02)11
+DM −CAD680.18 (0.15 to 0.23)14.48 (9.73 to 21.53)10.20 (6.64 to 15.67)
−DM +CAD740.02 (0.02 to 0.02)1.50 (1.02 to 2.22)1.85 (1.21 to 2.82)
+DM +CAD1990.29 (0.25 to 0.33)22.84 (16.14 to 32.34)16.67 (11.08 to 25.07)
  • *10-year cumulative incidence proportion accounting for the competing risk of death.

  • †Adjusted for age, sex, hypertension, microvascular disease, active smoking (imputed), body mass index (imputed), oral anticoagulant treatment, antiplatelet treatment, and statin treatment.

  • CAD, coronary artery disease; DM, diabetes mellitus.