Events | Events per 100 person years (95% CI) | 10-year cumulative incidence* (95% CI) | Unadjusted HR (95% CI) | Adjusted HR† (95% CI) | |
Peripheral artery disease | |||||
−DM −CAD | 1170 | 0.40 (0.38 to 0.43) | 3.53% (3.32 to 4.74) | 1 | 1 |
+DM −CAD | 293 | 0.81 (0.73 to 0.91) | 6.89% (6.11 to 7.73) | 1.98 (1.74 to 2.25) | 1.73 (1.51 to 1.97) |
−DM +CAD | 3759 | 1.02 (0.99 to 1.05) | 7.90% (7.65 to 8.16) | 2.48 (2.32 to 2.65) | 2.20 (2.04 to 2.37) |
+DM +CAD | 1354 | 2.10 (1.99 to 2.22) | 14.56% (13.80 to 15.34) | 5.00 (4.63 to 5.41) | 3.90 (3.55 to 4.28) |
Lower limb revascularization | |||||
−DM −CAD | 289 | 0.10 (0.09 to 0.11) | 0.89% (0.79 to 1.00) | 1 | 1 |
+DM −CAD | 63 | 0.17 (0.13 to 0.22) | 1.56% (1.19 to 2.02) | 1.73 (1.31 to 2.27) | 1.55 (1.16 to 2.05) |
−DM +CAD | 1090 | 0.29 (0.27 to 0.30) | 2.39% (2.24 to 2.54) | 2.89 (2.54 to 3.29) | 2.51 (2.17 to 2.91) |
+DM +CAD | 399 | 0.59 (0.53 to 0.65) | 4.48% (4.04 to 4.96) | 5.88 (5.05 to 6.84) | 4.61 (3.85 to 5.52) |
Lower limb amputation | |||||
−DM −CAD | 104 | 0.04 (0.03 to 0.04) | 0.34% (0.28 to 0.41) | 1 | 1 |
+DM −CAD | 100 | 0.27 (0.22 to 0.33) | 2.42% (1.96 to 3.95) | 7.77 (5.91 to 10.23) | 5.51 (4.09 to 7.43) |
−DM +CAD | 248 | 0.06 (0.06 to 0.07) | 0.59% (0.52 to 0.67) | 1.84 (1.46 to 2.31) | 2.02 (1.57 to 2.60) |
+DM +CAD | 330 | 0.48 (0.43 to 0.54) | 3.81% (3.40 to 4.25) | 13.86 (11.12 to 17.28) | 9.49 (7.27 to 12.39) |
Hip/femur amputation | |||||
−DM −CAD | 45 | 0.02 (0.01 to 0.02) | 1 | 1 | |
+DM −CAD | 24 | 0.06 (0.04 to 0.10) | 4.30 (2.62 to 7.06) | 3.31 (1.95 to 5.61) | |
−DM +CAD | 148 | 0.04 (0.03 to 0.05) | 2.54 (1.82 to 3.55) | 2.62 (1.81 to 2.79) | |
+DM +CAD | 108 | 0.16 (0.13 to 0.19) | 10.46 (7.39 to 14.82) | 7.41 (4.87 to 11.28) | |
Knee/lower leg amputation | |||||
−DM −CAD | 36 | 0.01 (0.01 to 0.02) | 1 | 1 | |
+DM −CAD | 37 | 0.10 (0.07 to 0.14) | 8.26 (5.22 to 13.07) | 5.19 (3.13 to 8.62) | |
−DM +CAD | 74 | 0.02 (0.02 to 0.02) | 1.58 (1.06 to 2.36) | 1.76 (1.14 to 2.74) | |
+DM +CAD | 123 | 0.18 (0.15 to 0.21) | 14.76 (10.18 to 21.41) | 9.00 (5.69 to 14.23) | |
Ankle/foot/toe amputation | |||||
−DM −CAD | 38 | 0.01 (0.01 to 0.02) | 1 | 1 | |
+DM −CAD | 68 | 0.18 (0.15 to 0.23) | 14.48 (9.73 to 21.53) | 10.20 (6.64 to 15.67) | |
−DM +CAD | 74 | 0.02 (0.02 to 0.02) | 1.50 (1.02 to 2.22) | 1.85 (1.21 to 2.82) | |
+DM +CAD | 199 | 0.29 (0.25 to 0.33) | 22.84 (16.14 to 32.34) | 16.67 (11.08 to 25.07) |
*10-year cumulative incidence proportion accounting for the competing risk of death.
†Adjusted for age, sex, hypertension, microvascular disease, active smoking (imputed), body mass index (imputed), oral anticoagulant treatment, antiplatelet treatment, and statin treatment.
CAD, coronary artery disease; DM, diabetes mellitus.